Levomycetin, 3% 25 ml

Pharmacotherapeutic group

Antibiotic

ATX code: D06AX02

Pharmacological Action

The active ingredient of the drug is chloramphenicol – a broad spectrum antibiotic with high antibacterial activity against pathogens of wound infection and various forms of pyo-inflammatory processes. Chloramphenicol is a bacteriostatic antibiotic that disrupts protein synthesis in a microbial cell (it has good lipophilicity, penetrates through the cell membrane of bacteria and reversibly binds to the substance 50S of bacterial ribosomes, where amino acid transfer to the growing peptide chains is delayed, which leads to disruption of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. It promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelialization. Resistance of microorganisms to chloramphenicol develops relatively slowly.

Indications

Bacterial skin infections caused by sensitive microorganisms, incl. infected burns (superficial and limited deep), bedsores, trophic ulcers, boils

Pharmacological effect

Pharmacotherapeutic group

Antibiotic

ATX code: D06AX02

Pharmacological action

The active ingredient of the drug is chloramphenicol, a broad-spectrum antibiotic with high antibacterial activity against pathogens of wound infections and various forms of purulent-inflammatory processes. Chloramphenicol is a bacteriostatic antibiotic that disrupts the process of protein synthesis in the microbial cell (it has good lipophilicity, penetrates the bacterial cell membrane and reversibly binds to the substance of 50S bacterial ribosomes, in which the movement of amino acids to growing peptide chains is delayed, which leads to disruption of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, and sulfonamides. Promotes cleansing and healing of burn wounds and trophic ulcers, accelerates epithelization. Resistance of microorganisms to chloramphenicol develops relatively slowly

Special instructions

During treatment, systematic monitoring of peripheral blood patterns is necessary. When taking ethanol simultaneously, disulfiram-like reactions may develop (skin hyperemia, tachycardia, nausea, vomiting, reflex cough, convulsions). Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.

Active ingredient

Chloramphenicol

Composition

Active ingredient:

Chloramphenicol (chloramphenicol) – 3 g

Excipient:

Ethanol (ethyl alcohol) 70% – up to 100 ml

Pregnancy

The use of the drug during pregnancy and breastfeeding is contraindicated.

Contraindications

Individual intolerance, suppression of bone marrow hematopoiesis, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, liver, kidney failure, skin diseases (eczema, psoriasis, fungal infections), neonatal period (up to 4 weeks)
With caution Early childhood, previous treatment with cytotoxic drugs or radiation therapy

Side Effects

Allergic reactions: skin rash, angioedema.
From the hematopoietic organs: rarely – thrombocytopenia, erythropenia, aplastic anemia, agranulocytosis, reticulocytopenia, leukopenia, granulocytopenia. If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

When used simultaneously with erythromycin, clindamycin, lincomycin, a mutual weakening of the effect is observed due to the fact that chloramphenicol can displace these drugs from the bound state or prevent their binding to the substance of 50S bacterial ribosomes. Reduces the antibacterial effect of penicillins and cephalosporins. If you are using the above or other medications (including over-the-counter medications), consult your doctor before using the drug.

Overdose

To date, no cases of drug overdose have been registered.

Recommendations for use

The use of the drug during pregnancy and breastfeeding is contraindicated.

Storage conditions

In a place protected from light at a temperature not exceeding 25 0C.
Keep out of the reach of children.

Shelf life

2 years.
Do not use after expiration date.

Manufacturer

Tver pharmaceutical factory, Russia