Levocetirizine-Teva, 5 mg 7 pcs.

The drug has antipruritic, antiexudative action. It does not have antiserotonin and anticholinergic effects. It prevents the development of various allergic reactions and significantly relieves them.

The administration in the indicated therapeutic doses does not cause sedation. It does not affect the electrocardiogram.

The active substance is levocetirizine – a representative of the group of competitive histamine antagonists. Completely blocks histamine H1-receptors and shows a high level of selectivity to H1-GR. It has an effect on the allergic reaction in the histamine-dependent stage.

Controlling eotaxins that stimulate transendothelial migration of eosinophils by completely blocking the expression of vascular cell adhesion molecule 1, significantly reduces vascular permeability, eosinophil migration and limits the release of inflammatory mediators.

Indications

Symptomatic treatment:

year-round allergic rhinitis;
seasonal allergic rhinitis;
chronic idiopathic urticaria.

Pharmacological effect

The drug has an antipruritic, antiexudative effect. Does not have antiserotonin and anticholinergic effects. Prevents the development and significantly facilitates the course of various allergic reactions.

Taken in the indicated therapeutic doses does not cause sedation. Does not affect electrocardiogram readings.

The active substance, levocetirizine, is a representative of the group of competitive histamine antagonists. Completely blocks histamine H1 receptors and shows a high level of selectivity for H1-GR. It influences the allergic reaction in the histamine-dependent stage.

By restraining eotaxins, which stimulate transendothelial migration of eosinophils, completely blocking the expression of vascular cell adhesion molecule 1, significantly reduces vascular permeability, migration of eosinophils and limits the process of release of inflammatory mediators.

Special instructions

Do not exceed the recommended daily dose.
The patient should be warned that drinking alcohol during treatment with levocetirizine is not recommended.

Active ingredient

Levocetirizine

Composition

1 tablet contains:

active substance:

Contraindications

Hypersensitivity to levocetirizine and other components of the drug; hypersensitivity to piperazine derivatives; end-stage renal failure (creatinine clearance less than 10 ml/min); lactose intolerance, lactase deficiency, glucose-galactose malabsorption; children under 6 years of age; pregnancy; breastfeeding period.

Side Effects

Nervous system: often – drowsiness, headache, agitation, aggression, convulsions; less often – dizziness, migraine.
Visual organs: visual impairment.
Cardiovascular system: tachycardia.
Respiratory system: dyspnea.
Gastrointestinal tract: often – dryness of the oral mucosa; less often – pain in the abdominal cavity; very rarely – dyspepsia, diarrhea, nausea, changes in liver function tests, hepatitis.
Musculoskeletal system: myalgia.
Metabolism: increase in body weight.
Allergic reactions: skin rash, itching, urticaria, anaphylaxis, angioedema.
Other: often – general fatigue, fatigue; less often – asthenia.

Interaction

A decrease in the clearance of cetirizine (16%) was observed with repeated administrations of theophylline (400 mg 1 time/day); however, the pharmacokinetics of theophylline did not change with simultaneous administration of cetirizine.

In susceptible patients, concomitant use of levocetirizine and ethanol or other CNS depressants may result in potentiation of the CNS depressant effect.

Overdose

Symptoms: drowsiness (in adults), agitation and anxiety, followed by drowsiness (in children).
Treatment is symptomatic: immediately after taking the drug, perform gastric lavage or induce artificial vomiting. The use of activated carbon and symptomatic and supportive therapy are recommended. There is no specific antidote. Hemodialysis is ineffective.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life

3 years

Manufacturer

Teva Pharmaceutical Enterprises Ltd., Israel