Korneregel, eye gel 5% 5 g

Corneal protector. The drug stimulates the regeneration processes.

The active ingredient of Corneregel is dexpanthenol/panthenol, a precursor of pantothenic acid which, therefore, has all the same biological properties as D-pantothenic acid, which, having transformed in the human body into coenzyme A, is involved in many metabolic processes.

Data obtained in animal experiments demonstrate an increase in fibroblast proliferation and a regenerating effect. When applied topically, dexpanthenol is able to compensate for the increased demand of damaged skin or mucous membranes for pantothenic acid.

The eye gel is highly viscous, which allows prolonged contact of dexpanthenol with the surface of the mucosa.

Pharmacokinetics

Tritium-labeled dexpanthenol has been shown to be absorbed through the skin.In order to increase time of contact of dexpanthenol aqueous solution with corneal epithelium Corner gel contains carbomer which due to its high molecular weight does not get into the eyeball tissue and is not absorbed into the systemic blood flow.

Indications

• Treatment of non-inflammatory keratopathies, such as corneal dystrophy, recurrent erosions, corneal lesions when wearing contact lenses;
• Treatment of corneal keratopathiesAs adjuvant therapy to stimulate healing of cornea and conjunctiva after trauma and burns (chemical and thermal) of the cornea;
• Accessory treatment for infective corneal lesions of bacterial, viral or fungal origin.

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Active ingredient

Dexpanthenol

Composition

Eye gel 5% transparent or slightly opalescent, colorless, easily flowable.

1 g dexpanthenol 50 mg

Supplementary substances:

cetrimide – 0.1 mg,

dinatrium edetate – 0.1 mg,

carbomer – 0.1 mg,

sodium hydroxide – 1.01 mg,

d/i water – 945.79 mg.

How to take, the dosage

It is used topically.

In the lower conjunctival sac of the affected eye, 1 drop 4 times a day, and 1 drop at bedtime.

Interaction

In cases where additional topical therapy with eye drops/ ointments is carried out, the interval between the administration of Korneregel and other ophthalmic drugs should be at least 15 minutes.

Owing to its physical properties, Korneregel may prolong the residence time of other ophthalmic drugs in the eye and thus enhance their effect. Therefore, Korneregel should be used last.

Special Instructions

Wearing of soft contact lenses is not recommended during treatment with the drug. If contact lenses are used, they should be removed before applying the gel and not inserted until 15 minutes after instillation of the drug.

The tube should be closed after each use and the tip of the tube should not touch the eye.

Application in patients with renal dysfunction Use with caution in patients with chronic renal failure.

Impact on driving and operating machinery

Patient should refrain during treatment from engaging in potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

Individual hypersensitivity to any of the ingredients of the drug.

The drug is used with caution in pregnancy and during breastfeeding (no clinical data available).

Side effects

Local reactions: itching, hyperemia, conjunctival edema, pain, foreign body sensation, increased lacrimation, transient “blurring” of vision.

Allergic reactions: very rare – hypersensitivity (itching, skin rashes).

Overdose

There are no data on overdose of Korneregel.

Pregnancy use

Since there are no data on plasma concentrations of dexpanthenol (pantothenic acid) after topical application in the form of eye gel, the use of Korneregel during pregnancy and/or during breastfeeding is possible only after consultation with a physician, when the expected benefits to the mother exceed the potential risk to the fetus and/or child.

Similarities

Korneregel, D-Panthenol, Pantoderm, Panthenol, Dexpanthenol, Panthenol-Teva, Bepanthen, D-Panthenol-Nizhpharm, Panthenol Pharmstandard