Klenzit, gel 0.1% 15 g

The active ingredient of the drug is a retinoid derivative – Adapalene, which has anti-inflammatory and comedolytic activity. Adapalene participates in normalization of epidermal differentiation and keratinization processes, inhibits formation of microcomedones and reduces manifestations of inflammation.

The mechanism of action of the active ingredient of Klenzit lies in its ability to influence specific gamma-receptors of the epidermal cells of the skin, reducing their adhesive surface in the mouths of oil-hair follicles.

In vivo and in vitro studies have proven that Adapalen has a pronounced anti-inflammatory effect due to its effect on inflammatory factors. It inhibits the metabolism of arachidonic acid and migration of leukocytes.

When the gel is applied externally, the systemic absorption of its active ingredient Adapalen is quite low, about 4% of the used dose.

From the systemic bloodstream, it is excreted by the liver.

Indications

Common acne (vulgar)

Ugric acne.

Active ingredient

Adapalene

Composition

1 gram of gel contains:

Active substance:

Adapalene 1 mg.

Associates:

Dinatrium edetate;

Carbomer 940 (carbopol 940);

Propylene glycol;

Methyl parahydroxybenzoate;

Phenoxyethanol;

Poloxamer 407;

Sodium hydroxide;

Purified water.

How to take, the dosage

Externally. Before applying the gel, the skin of the face should be cleaned and dried. Using a light touch, apply the gel evenly to the affected area once a day before going to bed, avoiding contact of the drug with the mucous membranes of the eyes and lips.

Therapeutic effect develops after 4-8 weeks of treatment, lasting improvement comes after 3 months of treatment. In some cases, due to transient skin irritation, treatment may be suspended until the signs of irritation disappear.

Repeated treatment is possible after consultation with a doctor.

Interaction

Because adapalene does not interact with oxygen and does not degrade when exposed to light, drugs such as clindamycin phosphate or benzoyl peroxide can be used at the same time to treat acne.

Special Instructions

Avoid getting gel in the eyes and on the lips.

In case of accidental contact with mucous membranes in the eyes, mouth or nose, rinse thoroughly with warm water.

Avoid direct sunlight, as skin irritation may occur. Treatment may be continued if sun exposure is minimized (use of sunglasses and hats).

The simultaneous use of cosmetic products with a drying and irritating effect on the skin (e.g., perfume or alcohol-containing products) is not recommended.

Adapalene applied to the skin in the evening may be combined with acne medications used in the morning.

Contraindications

• High sensitivity to the drug components
• Pregnancy
• Lactation (breastfeeding).

With caution The drug should be used with dermatitis, eczema.

Side effects

Dermatological reactions:

Skin irritation (treatment should be suspended until skin irritation disappears or the frequency of use is reduced).

Overdose

An overdose of the drug is unlikely.

Pregnancy use

The drug is not recommended during pregnancy and lactation (breastfeeding).