Ketonal, cream 5% 50 g 2 pcs

Ketoprofen is one of the most effective cyclooxygenase inhibitors. It also inhibits the activity of lipoxygenase and bradykinin. It stabilizes lysosomal membranes and prevents release of enzymes involved in the inflammatory process.

The main properties of ketoprofen are pronounced analgesic, anti-inflammatory and antipyretic effects. When using topical forms of ketoprofen for ligament injuries, back or joint pain, the analgesic effect of the drug is evident within 30 minutes after application.

Ketoprofen has no negative effect on joint cartilage.

Pharmacokinetics
Absorption

The penetration of local non-steroidal anti-inflammatory drugs through the skin depends on the physical and chemical properties of the components of the cream. The rate of release and absorption of ketoprofen in the form of cream for topical use depends on the filler of the drug. Compared with the oral form, the relative bioavailability of ketoprofen in the form of cream is about 5%. Ketoprofen in the form of cream mainly acts locally and has no systemic effect.

Distribution

Ketoprofen primarily binds to plasma proteins (99%). It penetrates into the joint tissues, including the synovial fluid, and reaches therapeutic concentrations there. At the same time the concentration of ketoprofen in blood plasma remains insignificant. When topically applied as a cream the maximum concentration of ketoprofen in plasma is observed after 6 hours.

Significant concentrations are present in the subcutaneous fatty tissue, periarticular tissues and synovial fluid. The action of the drug in the tissues lasts up to 12 hours.

Metabolism and excretion

Ketoprofen is metabolized in the liver to form conjugates which are eliminated mainly by the kidneys. Metabolism of ketoprofen does not depend on age, the presence of severe renal failure or cirrhosis. Ketoprofen is gradually excreted by the kidneys.

Indications

Symptomatic therapy – reduction of pain and inflammation – for the following conditions:

osteoarthritis of various localizations;

periarthritis, tendinitis, bursitis, myalgia, neuralgia, radiculitis;

musculoskeletal system injuries (including sports injuries).

Musculoskeletal injuries (including sports), muscle and ligament contusions, sprains, ligament and muscle tendon tears.

Active ingredient

Composition

How to take, the dosage

For external use.

A small amount of cream (3-5 cm) is applied by lightly rubbing with a thin layer on the skin of the inflamed or painful area of the body according to its area 2 times a day. The duration of the treatment course without medical consultation shall not exceed 14 days.

If necessary, Ketonal® Cream may be combined with other dosage forms of Ketonal® (capsules, tablets, rectal suppositories, solution for intravenous and intramuscular injection).

The maximum dose of ketoprofen is 200 mg/day.

The occlusive dressing is not recommended.

If you forget to apply the cream, apply it at the time the next dose is due, but do not double it.

Interaction

Special Instructions

Contraindications

Hypersensitivity to ketoprofen or other drug components, as well as to salicylates, thiaprofenoic acid or other NSAIDs, fenofibrate, ultraviolet (UV) ray blockers, fragrances;

A history of bronchial asthma or allergic rhinitis after use of NSAIDs and salicylates;

The third trimester of pregnancy;

childhood (under 15 years of age);

Violation of the integrity of the skin in the area where the cream is applied (eczema, acne, blistering dermatitis, open or infected wounds);

A history of photosensitivity reactions;

exposure to sunlight, including indirect sunlight

Injury to sunlight, including indirect sunlight and UV exposure in a tanning bed for the duration of treatment and up to 2 weeks after discontinuation.

You should consult your doctor before using Ketonal® Cream if you have:

disorder of liver and/or kidney function;

erosive-ulcerative gastrointestinal tract involvement;

blood disorders;

bronchial asthma;

chronic heart failure.

Side effects

According to the World Health Organization (WHO), adverse effects are classified according to their frequency of development as follows: Very common (≥1/10), common (≥1/100 to <1/10), infrequent (≥1/1000 to <1/100), rare (≥1/10000 to <1/1000), very rare (<1/10000); frequency unknown – the incidence could not be determined from available data.

Immune system disorders
frequency unknown: anaphylactic shock, angioedema (Quincke’s edema), hypersensitivity reactions.

Gastrointestinal tract disorders
very rare: peptic ulcer, bleeding, diarrhea.

Skin and subcutaneous tissue disorders
infrequent: local skin reactions such as erythema, eczema, itching and burning;
rare: photosensitivity reactions, urticaria.

There have been rare reports of more severe reactions, such as bullous or pox eczema, which may extend beyond the area of application or become generalized.

Recreational renal and urinary tract disorders
very rare: worsening of renal function in patients with chronic renal failure.
If any side effects occur, discontinue use of the drug and consult a physician.

Overdose

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