Iodine, alcohol 5% 25 ml

An antiseptic agent. The main active ingredient is molecular iodine, which has antiseptic properties. When applied to extensive skin surfaces, iodine has a resorptive effect: it actively affects metabolism, participates in the synthesis of thyroxine, has a proteolytic effect. Ethyl alcohol is a high molecular weight compound which slows down iodine excretion and reduces its irritating effect on tissues.

It has a bactericidal effect, both on Gram-positive flora (most active on Streptococcus and Escherichia coli) and on pathogenic fungi and yeast. Staphylococcus aureus is more persistent flora, but it disappears with long-term use of the drug in 80% of cases. Pseudomonas bacillus is resistant. The drug is little toxic.

Pharmacokinetics

On contact with the skin 30% is converted to iodides, and the remainder penetrates tissues and organs, selectively absorbed by the thyroid gland. It is excreted by the kidneys (mainly), intestines, sweat glands, with milk during lactation.

Indications

Inflammatory and infectious skin diseases, abrasions, cuts, microtraumas, wounds; inflammatory infiltrates; treatment of wound edges and skin before injections, punctures, catheterization.

Pharmacological effect

Pharmacotherapeutic group: antiseptic.

ATX code [D08AG03]

Pharmacological properties:

Pharmacodynamics

Antiseptic. The main active ingredient is molecular iodine, which has antiseptic properties. When applied to large surfaces of the skin, iodine has a resorptive effect: it actively affects metabolism, enhances dissimilation processes, participates in the synthesis of thyroxine, and has a proteolytic effect.

It has a bactericidal effect on gram-positive flora (most active on streptococcal flora and E. coli), as well as on pathogenic fungi and yeast. A more persistent flora is staphylococcus, but with prolonged use of the drug in 80% of cases it disappears. Pseudomonas aeruginosa is resistant.

The drug is slightly toxic.

Pharmacokinetics

Upon contact with skin, 30% is converted into iodides, and the rest into active iodine. Partially absorbed. The absorbed part penetrates tissues and organs and is selectively absorbed by the thyroid gland. It is secreted by the kidneys (mainly), intestines, sweat and mammary glands.

With caution:

Children’s age up to 12 years.

Special instructions

When used together with yellow mercury ointment, the formation of mercury iodide, which has a cauterizing effect, is possible. Light and temperature above 40℃ accelerate the breakdown of active iodine. The drug should have a dark brown color. Discoloration of the solution indicates the destruction of the complex with the transition of active iodine to iodide ion and a decrease in the effectiveness of the drug. Alkaline or acidic environment, the presence of fat, pus, blood weaken the antiseptic activity.

Impact on the ability to drive vehicles and machinery:
The use of the drug according to the instructions for medical use does not have a negative impact on the performance of potentially hazardous activities that require special attention and quick reactions. Avoid contact with eyes.

Active ingredient

Iodine, (Potassium iodide, Ethanol)

Composition

Active ingredient:
Crystalline iodine – 50 g.
Excipients:
Potassium iodide – 20 g,
Ethanol (ethyl alcohol) 95% – 500 ml,
Purified water – up to 1000 ml.

Pregnancy

Use with caution during pregnancy and breastfeeding.

Contraindications

Hypersensitivity, thyrotoxicosis, dermatitis herpetiformis.

Side Effects

For external use: skin irritation; with prolonged use on large wound surfaces – iodism (rhinitis, urticaria, Quincke’s edema, salivation, lacrimation, acne).

Interaction

Pharmaceutically incompatible with essential oils, ammonia solutions, white sedimentary mercury (an explosive mixture is formed).

Overdose

In case of overdose, phenomena of iodism, irritation, and burns are possible. Treatment is symptomatic, wash off excess drug with clean running water.

Storage conditions

In a tightly closed package, in a place protected from light, at a temperature not lower than
0 °C.
Keep out of the reach of children.

Shelf life

3 years.
Do not use after expiration date.

Manufacturer

Samaramedprom JSC, Russia