Iodantinopyrin, tablets 100 mg 50 pcs

Pharmacodynamics.
Jodantipyrine has anti-inflammatory, immunostimulatory and interferonogenic properties. It stabilizes biological membranes and inhibits virus penetration into the cell. It is an active inducer of alpha and beta interferon, stimulates cellular and humoral immunity. It is active against tick-borne encephalitis virus, hemorrhagic fever with renal syndrome.

Pharmacokinetics.
Fastly absorbed from the gastrointestinal tract, bioavailability is 80%. Up to 95% is metabolized in the liver. Urinary excretion through the kidneys by active transport to the renal tubules: 3-5% unchanged, 80-90%) – inactive metabolites. It has high affinity to tissue proteins. Binding to blood proteins is 25%. The elimination half-life is about 6 hours.

Indications

Yodantipyrine is used for the treatment and prevention of tick-borne encephalitis in adults, for the complex treatment of hemorrhagic fever with renal syndrome.

Pharmacological effect

Pharmacodynamics.
Yodantipyrine has anti-inflammatory, immunostimulating and interferonogenic properties. Stabilizes biological membranes and delays the penetration of the virus into the cell. It is an active inducer of alpha and beta interferon, stimulates cellular and humoral immunity. Active against tick-borne encephalitis virus, hemorrhagic fever with renal syndrome.

Pharmacokinetics.
Rapidly absorbed from the gastrointestinal tract, bioavailability is 80%. Up to 95% is metabolized in the liver. Excretion in urine through the kidneys by active transport into the renal tubules: 3-5% unchanged, 80-90%) – inactive metabolites. Has a high affinity for tissue proteins. Blood protein binding is 25%. The half-life is about 6 hours.

Special instructions

In the treatment and prevention of tick-borne encephalitis, the combined use of Yodantipirin and anti-tick immunoglobulin is not recommended. For focal forms of tick-borne encephalitis, a specific immunoglobulin is first prescribed according to the usual regimen, and after 2-3 days Yodantipyrine is prescribed in the indicated dosages.

Active ingredient

Iodophenazone

Composition

Active substance: iodantipyrine – 0.1 g
Excipients: potato starch, glucose, magnesium stearate, low molecular weight medical polyvinylpyrrolidone.

Contraindications

Individual intolerance to Yodantipirin and other iodine-containing drugs, hyperfunction of the thyroid gland, severe liver and kidney dysfunction, pregnancy and lactation, childhood.

Side Effects

The drug has low toxicity and is quite well tolerated. In some cases, dyspeptic symptoms, skin rash, itching, angioedema and other allergic reactions are possible. When you stop taking the drug, these phenomena disappear.

Interaction

Antacids and H2 receptor antagonists reduce drug absorption. When taken together with oral hypoglycemic drugs, barbiturates, tricyclic antidepressants, and indirect-acting anticoagulants, Yodantipyrine enhances their effect, displacing them from protein binding.

Storage conditions

Store in a dry place, protected from light, at a temperature not exceeding 25 °C. Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date stated on the package.

Manufacturer

Tatchimpharmpreparaty, Russia