Ibuprofen-Chemopharm, 400 mg 30 pcs

The mechanism of action of ibuprofen, a propionic acid derivative of the group of nonsteroidal anti-inflammatory drugs (NSAIDs), is due to the inhibition of the synthesis of prostaglandins – mediators of pain, inflammation and hyperthermia.

Indications

Headache, toothache, migraine, painful menstruation, neuralgia, back pain, joint pain, muscle and rheumatic pain, fever due to flu and colds.

Pharmacological effect

The mechanism of action of ibuprofen, a derivative of propionic acid from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins – mediators of pain, inflammation and hyperthermic reaction.

Special instructions

It is recommended to take the drug for the shortest possible course and in the minimum effective dose necessary to eliminate symptoms. If you need to take the drug for more than 10 days, you must consult a doctor.
In patients with bronchial asthma or an allergic disease in the acute stage, as well as in patients with a history of bronchial asthma/allergic disease, the drug may provoke bronchospasm.

Active ingredient

Ibuprofen

Composition

1 film-coated tablet contains:

active ingredient:

Pregnancy

Contraindicated in the third trimester of pregnancy, in the first and second trimesters – with caution.

During breastfeeding, the use of the drug is possible (with caution).

Contraindications

Hypersensitivity to ibuprofen or any of the components included in the drug;
complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid (ASA) or other NSAIDs (including a history);
erosive and ulcerative diseases of the gastrointestinal tract (including gastric and duodenal ulcers, Crohn’s disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding);
a history of bleeding or perforation of a gastrointestinal ulcer caused by the use of NSAIDs;
severe heart failure (class IV according to the New York Heart Association (NYHA) classification);
severe liver failure or active liver disease;
severe renal failure (creatinine clearance <30 ml/min), confirmed hyperkalemia; decompensated heart failure, the period after coronary artery bypass grafting; cerebrovascular or other bleeding; hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis; pregnancy (III trimester); children's age up to 12 years.
With caution
If you have the conditions listed in this section, you should consult your doctor before using the drug.

Side Effects

The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.

Interaction

The simultaneous use of ibuprofen with the following drugs should be avoided:

Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg per day) prescribed by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent is possible after starting ibuprofen).

Other NSAIDs, in particular selective COX-2 inhibitors: the simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.

Overdose

In children, overdose symptoms may occur after taking a dose exceeding 400 mg/kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. The half-life of the drug in case of overdose is 1.5-3 hours.

Storage conditions

At a temperature not exceeding 25 °C in consumer packaging.

Shelf life

4 years.

Manufacturer

Hemofarm A.D., Serbia