Hydrocortisone-Pos, eye ointment 2.5% 2.5g

Pharmacotherapeutic group – glucocorticosteroid for topical use.
TACH Code S01BA02

Pharmacodynamics

The drug contains as active ingredient hydrocortisone acetate – glucocorticosteroid.

When used topically, hydrocortisone acetate suppresses inflammatory and allergic reactions occurring in the outer membranes and anterior segment of the eye.

The action of hydrocortisone acetate, like other corticosteroids, is based on suppression of leukocyte and tissue macrophage function. It restricts migration of leukocytes, macrophages and mast cells to the area of inflammation and inhibits formation of interleukin-1. It promotes stabilization of lysosomal membranes, thus reducing the concentration of pro-theolytic enzymes in the area of inflammation. Reduces capillary permeability caused by histamine release. Inhibits fibroblast activity and collagen formation. It inhibits the activity of phospholipase A2 which leads to the suppression of prostaglandin and leukotriene synthesis.

Pharmacokinetics

Possible penetration of hydrocortisone acetate through the cornea into the moisture of the anterior chamber of the eye due to its lipophilic properties. Penetration of hydrocortisone acetate into the tissues depends on the condition of the cornea and increases significantly in case of inflammation or damage to the ocular mucosa.

Indications

Allergic conjunctivitis, blepharitis, blepharoconjunctivitis;
Acute and chronic iritis, iridocyclitis;
Inflammatory phenomena after surgery on the eyeball;
Suppression of neovascularization after keratitis and chemical burns.

Pharmacological effect

Pharmacotherapeutic group – glucocorticosteroid for local use.
ATX code S01BA02

Pharmacodynamics

The drug contains hydrocortisone acetate, a glucocorticosteroid, as the active substance.

When applied topically, hydrocortisone acetate suppresses inflammatory and allergic reactions that occur in the area of ​​the outer membranes and the anterior segment of the eye.

The action of hydrocortisone acetate, like other corticosteroids, is based on the suppression of the function of leukocytes and tissue macrophages. Limits the migration of leukocytes, macrophages and mast cells to the area of ​​inflammation and suppresses the formation of interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of ​​inflammation. Reduces capillary permeability due to the release of histamine. Suppresses fibroblast activity and collagen formation. Inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes.

Pharmacokinetics

It is possible for hydrocortisone acetate to penetrate through the cornea into the moisture of the anterior chamber of the eye due to its lipophilic properties. The penetration of hydrocortisone acetate into the tissue depends on the condition of the cornea and increases significantly in the case of inflammation or damage to the ocular mucosa.

Special instructions

During treatment with Hydrocortisone-POS eye ointment 1%, 2.5% it is not recommended to use contact lenses.
Immediately after using the drug Hydrocortisone-POS eye ointment 1%, 2.5%, a short-term disturbance in visual acuity may occur, leading to a slowdown in mental and physical reactions. Therefore, it is not recommended to use the drug immediately before working with machinery or driving vehicles.

Active ingredient

Hydrocortisone

Composition

1 g of Hydrocortisone-POS 2.5% eye ointment contains:

Active substance: hydrocortisone acetate 25.0 mg

Excipients: petroleum jelly, liquid paraffin, lanolin.

Pregnancy

To date, there are no clinical trial data regarding the use of the drug Hydrocortisone-POS 1%, 2.5% eye ointment during pregnancy, lactation, or in children. It is possible to use the drug Hydrocortisone-POS 1%, 2.5% eye ointment for the treatment of children over 1 year of age, pregnant and nursing mothers as prescribed by the attending physician, if the expected therapeutic effect exceeds the risk of developing possible side effects. The duration of use of the drug in this category of patients is no more than 7-10 days.

Contraindications

Hypersensitivity to any component of the drug;
Superficial corneal herpes and other viral eye diseases;
Violations of the integrity of the epithelium and damage to the cornea;
Tuberculous, bacterial or fungal eye infections;
Trachoma;
Vaccination period.

Side Effects

If, during treatment with Hydrocortisone-POS eye ointment 1%, 2.5%, you develop a side effect not listed in this instruction, or you are not sure about the effectiveness of the drug, please inform your doctor or pharmacist.
In very rare cases, allergic reactions are possible, such as burning, scleral injection, contact dermatitis, dermatoconjunctivitis, eyelid eczema.

Long-term use of the drug can cause secondary glaucoma and complicated cataracts, therefore, when using the drug for more than 2 weeks, as well as in patients with a history of glaucoma, it is recommended to regularly monitor intraocular pressure.

If side effects occur, you should stop using the drug and contact your doctor (ophthalmologist) as soon as possible.

Interaction

The simultaneous use of Hydrocortisone-POS eye ointment 1%, 2.5% and other drugs that can cause an increase in intraocular pressure (for example, atropine and other cholinergic drugs) may further increase intraocular pressure, especially in patients predisposed to this.

Overdose

When applied topically at the recommended dose, no overdose symptoms were observed.

Storage conditions

Store at a temperature not exceeding 25ºС. Keep out of the reach of children!

Shelf life

In unopened original packaging: 3 years.
Do not use after the expiration date stated on the package.

Manufacturer

Ursafarm Arzneimittel GmbH, Germany