Holitilin, 400 mg capsules 14 pcs

Notropic remedy. Central cholinostimulant containing 40.5% of metabolically protected choline.

It provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates reticular formation. Increases the linear velocity of blood flow, promotes normalization of spatiotemporal characteristics of spontaneous bioelectrical activity of the brain, regress of focal neurological symptoms and restoration of consciousness; has a positive effect on cognitive and behavioral reactions of patients with cerebral vascular diseases (discirculatory encephalopathy and residual effects of cerebral circulatory disorders).

It has a preventive and corrective effect on pathogenetic factors of involutional psychoorganic syndrome, reduces cholinergic activity. Stimulates dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission and plasticity of neuronal membranes. It has no effect on the reproductive cycle and has no teratogenic, mutagenic action.

Pharmacokinetics

Absorption is 88%. Easily penetrates through the blood-brain barrier (when administered orally, the concentration in the brain is 45% of that in plasma). It is excreted mainly by lungs as carbon dioxide (85%) and also by the kidneys and intestines (15%).

Indications

In complex therapy for:

Active ingredient

Composition

How to take, the dosage

Internal, 0.4 g 3 times a day, for 3-6 months.

In the subacute period of craniocerebral trauma 0.8 g in the morning and 0.4 g during the day for 6 months.

Interaction

Drug interactions of the drug have not been established.

Special Instructions

When treating, caution should be exercised when driving motor vehicles and engaging in other potentially dangerous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity;

Hemorrhagic stroke (acute stage);

Pregnancy and lactation;

Children under 18 years of age.

Side effects

Digestive system disorders:gastritis, peptic ulcer, pharyngitis.

Nervous system disorders: nervousness, cerebral ischemia, seizures, hyperkinesia, dizziness.

Other:allergic reactions, increased frequency of urination.

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