Holitilin, 400 mg capsules 14 pcs

Notropic remedy. Central cholinostimulant containing 40.5% of metabolically protected choline.

It provides synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates reticular formation. Increases the linear velocity of blood flow, promotes normalization of spatiotemporal characteristics of spontaneous bioelectrical activity of the brain, regress of focal neurological symptoms and restoration of consciousness; has a positive effect on cognitive and behavioral reactions of patients with cerebral vascular diseases (discirculatory encephalopathy and residual effects of cerebral circulatory disorders).

It has a preventive and corrective effect on pathogenetic factors of involutional psychoorganic syndrome, reduces cholinergic activity. Stimulates dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission and plasticity of neuronal membranes. It has no effect on the reproductive cycle and has no teratogenic, mutagenic action.

Pharmacokinetics

Absorption is 88%. Easily penetrates through the blood-brain barrier (when administered orally, the concentration in the brain is 45% of that in plasma). It is excreted mainly by lungs as carbon dioxide (85%) and also by the kidneys and intestines (15%).

Indications

In complex therapy for:

Traumatic brain injury with predominantly brain stem level of damage (acute period);
Cerebrovascular insufficiency;
Psychoorganic syndrome against the background of degenerative diseases and involutional processes of the brain;
Multi-infarct dementia.

Pharmacological effect

Nootropic drug. Central anticholinergic stimulant, which contains 40.5% metabolically protected choline.

Provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation. Increases the linear speed of blood flow, promotes normalization of the spatiotemporal characteristics of spontaneous bioelectrical activity of the brain, regression of focal neurological symptoms and restoration of consciousness; has a positive effect on the cognitive and behavioral reactions of patients with vascular diseases of the brain (dyscirculatory encephalopathy and residual effects of cerebrovascular accident).

It has a preventive and corrective effect on the pathogenetic factors of involutional psychoorganic syndrome, reduces cholinergic activity. Stimulates the dose-dependent release of acetylcholine under physiological conditions; participating in the synthesis of phosphatidylcholine (membrane phospholipid), improves synaptic transmission and plasticity of neuronal membranes. Does not affect the reproductive cycle and does not have a teratogenic or mutagenic effect.

Pharmacokinetics

Absorption – 88%. Easily penetrates the blood-brain barrier (when taken orally, the concentration in the brain is 45% of that in plasma). It is excreted primarily by the lungs, in the form of carbon dioxide (85%), as well as by the kidneys and intestines (15%).

Special instructions

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Choline alphoscerate

Composition

1 capsule contains:
Active substance:
Choline alfoscerate hydrate (Glycerylphosphorylcholine hydrate), in terms of choline alfoscerate (L-a-glycerophosphorylcholine) 400 mg.
Excipients:
Purified water;
Macrogol (polyethylene glycol 400);
Povidone (Plasdon C-15 or Kollidon® 17 PF).
Composition of soft gelatin capsule:
Delatin;
Glycerol (glycerin);
Methylparaben (methyl parahydroxybenzoate);
Propylparaben (propyl parahydroxybenzoate);
Sorbitol (sorbitol);
Titanium dioxide;
Iron oxide yellow dye;
Iron oxide red dye;
Iron oxide dye black;
Purified water.

Contraindications

Hypersensitivity;

Hemorrhagic stroke (acute stage);

Pregnancy and lactation;

Children under 18 years of age.

Side Effects

From the digestive system: gastritis, gastric ulcer, pharyngitis.

From the nervous system: nervousness, cerebral ischemia, convulsions, hyperkinesia, dizziness.

Other: allergic reactions, increased urination.

Interaction

No drug interactions have been established.

Manufacturer

Artlife LLC, Russia