Heparin 5000 IU/ml 5 ml, 5 pcs.

The mechanism of action of sodium heparin is based primarily on its binding to antithrombin III, which is a natural inhibitor of activated clotting factors – IIa (thrombin), IXa, Ha, XIa and XIIa. Sodium heparin binds to antithrombin III and causes conformational changes in its molecule.

Indications

Active ingredient

Composition

Active substance:

Heparin sodium

How to take, the dosage

Intravenous (infusion or injection) or subcutaneous, initial dose is intravenous (injection) 5000 IU, maintenance: continuous intravenous infusion 1000-2000 IU/h (20000-40000 IU/day), previously diluted in 1000 ml isotonic NaCl solution; regular intravenous injections of 5000-10000 IU every 4-6 h; subcutaneous (deep) IU 15000-20000 every 12 h or IU 8000-10000 every 8 h.

Interaction

Special Instructions

Contraindications

Hypersensitivity;

Hemorrhagic diathesis, hemophilia, vasculitis, thrombocytopenia (including one caused by history of heparin. caused by a history of heparin), bleeding, leukemia, increased vascular permeability, polyps, malignant neoplasms and GI ulcers, esophageal varices, severe uncontrolled arterial hypertension, acute bacterial endocarditis, trauma (especially brain injury), recent eye, brain and spine surgery, severe liver and/or kidney dysfunction.

Side effects

Nervous system and sensory organs: dizziness, headache.

Cardiovascular system and blood (hematopoiesis, hemostasis): Thrombocytopenia (6% of patients) – early (2-4 days of treatment) and late (autoimmune), in rare cases with fatal outcome; hemorrhagic complications – bleeding from the GI tract or urinary tract, retroperitoneal bleeding in the ovaries, adrenal (with the development of acute adrenal insufficiency).

Gastrointestinal system disorders: decreased appetite, nausea, vomiting, diarrhea, increased level of transaminases in blood.

Allergic reactions: skin hyperemia, drug fever, urticaria, rash, skin itching, bronchospasm, anaphylactoid reactions, anaphylactic shock.

Others: with long-term use – alopecia, osteoporosis, calcification of soft tissues, inhibition of aldosterone synthesis; injection reactions – irritation, hematoma, painfulness when inserted.

Overdose

Pregnancy use

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