Hepabene, capsules 30 pcs
€17.90 €14.91
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Pharmacotherapeutic group:choleretic agent of herbal origin.
ATX code: A05AX
Pharmacological action
Hepabene is a combination drug, which includes substances of herbal origin – extract of chokecherry and milk thistle extract.
Pharmacodynamics
The extract of melanax contains fumarin alkaloid with choleretic action. By normalizing the motor-evacuation function of the biliary tract (biliary) and tone of the sphincter of Oddi, fumarin facilitates the flow of bile into the duodenum.
The milk thistle fruit extract contains silymarin – a mixture of flavolignans – which has a hepatoprotective effect in acute and chronic intoxications due to the ability to bind free oxygen radicals, hepatotoxic substances and the presence of moderate antioxidant and membrane stabilizing properties.
Reproductive toxicity, genotoxicity and carcinogenicity studies of the active ingredients of the drug have not been conducted.
Studies of the general toxicity of the extract of melilot and the extract of milk thistle fruits under repeated use in the experiment and tolerability under clinical conditions showed no appreciable toxic effects and no danger to humans.
Pharmacokinetics
. After oral administration, the flavolignans constituent of silymarin undergo intestinal-hepatic recirculation, being excreted mainly with the bile and, to a lesser extent, with the kidneys.
Indications
Liver damage, Liver cirrhosis, Exposure to adverse factors, biliary dyskinesia, Hepatitis, Alcoholism, Poisoning, After a course of antibiotic therapy A herbal medicine to stimulate bile secretion and relieve symptoms of functional dyspepsia, such as: feeling of bloating, flatulence.
Use of Hepabene is based on the long-term experience of its use for this indication.
Active ingredient
Milk thistle fruit, Melon herb
Composition
1 capsule contains:
active ingredients:dried melon grass extract (corresponding to 4.13 mg of the sum of fumaric alkaloids in terms of protopin) 275.10 mg; milk thistle fruit extract dry (corresponding to 50 mg of silymarin, including. at least 22 mg of silybin)* 83.33-100.00 mg;
auxiliary substances: microcrystalline cellulose (type 102)* 63.20-79.87 mg, corn starch 20.10 mg, talc 8.40 mg, macrogol-6000 4.50 mg, copovidone 4.50 mg, colloidal silicon dioxide 2.10 mg, magnesium stearate 2.10 mg; coating: gelatin 79.94 mg, iron oxide yellow dye 0.67 mg, iron oxide red dye 0.15 mg, iron oxide black dye 0.04 mg, titanium dioxide 1.29 mg, purified water 13.92 mg.
* The amount of milk thistle fruit extract dry depends on its actual activity and should contain 50 mg silymarin. Microcrystalline cellulose is added in the amount necessary to compensate and to obtain the contents of a capsule with a theoretical mass of 480.00 mg.
How to take, the dosage
Capsules are taken orally before meals, without chewing, with plenty of water.
Adults take 1 capsule 3 times a day for two weeks.
If after treatment the improvement does not come or symptoms worsen or new symptoms appear it is necessary to consult a physician. Use the drug only according to the indications, the method of administration and in the doses specified in the instructions.
Interaction
Studies of drug interaction of the drug Hepabene were not conducted.
When using Silymarin together with oral contraceptives and drugs used in hormonal replacement therapy, the effect of the latter may decrease.
Silymarin may increase the effects of such drugs as diazepam, alprazolam, ketoconazole, lovastatin, atorvastatin, vinblastine due to its inhibitory effect on cytochrome P450 isoenzymes.
If you use the above or other drugs (including over-the-counter drugs), consult your doctor before using the drug Hepabene.
Special Instructions
Use of the drug is contraindicated in children and adolescents under 18 years of age, because there is no data on its use in this category of patients.
Impact on the ability to drive vehicles, mechanisms
There are no data on the drug effect on the ability to drive vehicles and engage in other potentially dangerous activities requiring increased concentration and rapid psychomotor reactions.
Synopsis
Solid gelatin capsules № 0 with opaque cap and body of light brown color. The contents of capsules – powder from light brown to dark brown heterogeneous color with white or yellowish or gray flecks. Conglomerates or seals are allowed.
Contraindications
– individual hypersensitivity to the ingredients of the drug, as well as to other plants of the family of asters (Compositae);
– acute inflammatory diseases of the liver, cholelithiasis, acute and chronic diseases of the biliary tract;
– childhood under 18 years.
With caution
With caution Prescribed for patients with hormonal disorders (endometriosis, uterine myoma, breast, ovarian and uterine carcinoma, prostate carcinoma) because of the possible estrogen-like effect of silymarin.
Side effects
Allergic reactions are possible.
Laxative action and increased diuresis may occur.
There are no data on the frequency of adverse events.
If you have side effects mentioned in the instructions or they worsen, or if you notice any other side effects not mentioned in the instructions, inform your physician.
Overdose
So far, no cases of overdose have been registered.
In case of accidental ingestion of a high dose it is necessary to induce vomiting, gastric lavage, take activated charcoal, conduct symptomatic treatment, if necessary.
Pregnancy use
Due to a lack of special studies, the use of the drug is contraindicated in pregnancy and during breast-feeding.
Weight | 0.030 kg |
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Shelf life | 3 years. Do not use after the expiration date! |
Conditions of storage | At the temperature not more than 25 °C, in the original package. Keep out of reach of children! |
Manufacturer | Merkle GmbH, Germany |
Medication form | capsules |
Brand | Merkle GmbH |
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