Hepabene, capsules 30 pcs

Pharmacotherapeutic group:choleretic agent of herbal origin.

ATX code: A05AX

Pharmacological action

Hepabene is a combination drug, which includes substances of herbal origin – extract of chokecherry and milk thistle extract.

Pharmacodynamics

The extract of melanax contains fumarin alkaloid with choleretic action. By normalizing the motor-evacuation function of the biliary tract (biliary) and tone of the sphincter of Oddi, fumarin facilitates the flow of bile into the duodenum.

The milk thistle fruit extract contains silymarin – a mixture of flavolignans – which has a hepatoprotective effect in acute and chronic intoxications due to the ability to bind free oxygen radicals, hepatotoxic substances and the presence of moderate antioxidant and membrane stabilizing properties.

Reproductive toxicity, genotoxicity and carcinogenicity studies of the active ingredients of the drug have not been conducted.

Studies of the general toxicity of the extract of melilot and the extract of milk thistle fruits under repeated use in the experiment and tolerability under clinical conditions showed no appreciable toxic effects and no danger to humans.

Pharmacokinetics

. After oral administration, the flavolignans constituent of silymarin undergo intestinal-hepatic recirculation, being excreted mainly with the bile and, to a lesser extent, with the kidneys.

Indications

Active ingredient

Composition

1 capsule contains:

active ingredients:dried melon grass extract (corresponding to 4.13 mg of the sum of fumaric alkaloids in terms of protopin) 275.10 mg; milk thistle fruit extract dry (corresponding to 50 mg of silymarin, including. at least 22 mg of silybin)* 83.33-100.00 mg;

auxiliary substances: microcrystalline cellulose (type 102)* 63.20-79.87 mg, corn starch 20.10 mg, talc 8.40 mg, macrogol-6000 4.50 mg, copovidone 4.50 mg, colloidal silicon dioxide 2.10 mg, magnesium stearate 2.10 mg; coating: gelatin 79.94 mg, iron oxide yellow dye 0.67 mg, iron oxide red dye 0.15 mg, iron oxide black dye 0.04 mg, titanium dioxide 1.29 mg, purified water 13.92 mg.

* The amount of milk thistle fruit extract dry depends on its actual activity and should contain 50 mg silymarin. Microcrystalline cellulose is added in the amount necessary to compensate and to obtain the contents of a capsule with a theoretical mass of 480.00 mg.

How to take, the dosage

Interaction

Special Instructions

Synopsis

Contraindications

– individual hypersensitivity to the ingredients of the drug, as well as to other plants of the family of asters (Compositae);

– acute inflammatory diseases of the liver, cholelithiasis, acute and chronic diseases of the biliary tract;

– childhood under 18 years.

With caution

With caution Prescribed for patients with hormonal disorders (endometriosis, uterine myoma, breast, ovarian and uterine carcinoma, prostate carcinoma) because of the possible estrogen-like effect of silymarin.

Side effects

Overdose

Pregnancy use