Guttalax, drops 7.5 mg/ml, 15 ml

Guttalax is a laxative drug. The active ingredient, sodium picosulfate, is a laxative of the triarylmethane group.

As a local laxative, sodium picosulfate after bacterial cleavage in the large intestine has a stimulating effect on the mucous membrane of the large intestine, increasing peristalsis, helps to accumulate water and electrolytes in the large intestine. This leads to stimulation of the act of defecation, reduction of evacuation time and softening of stools.

Pharmacokinetics

After oral administration, sodium picosulfate enters the colon. Absorption of the drug is insignificant, which rules out its enterohepatic circulation.

In the colon, sodium picosulfate is broken down to form the active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane. The time of development of the laxative effect of the drug is determined by the rate of release of the active metabolite and is 6-12 hours.

A small part of the drug enters the systemic bloodstream.

There is no correlation between the laxative effect of the active metabolite and its concentration in blood serum.

Indications

Chronic constipation

Pharmacological effect

Guttalax is a laxative drug. The active substance, sodium picosulfate, is a laxative of the triarylmethane group.

As a local laxative, sodium picosulfate, after bacterial breakdown in the colon, has a stimulating effect on the colon mucosa, increasing peristalsis, and promoting the accumulation of water and electrolytes in the colon. This leads to stimulation of the act of defecation, reduction of evacuation time and softening of the stool.

Pharmacokinetics

After ingestion, sodium picosulfate enters the colon. Absorption of the drug is insignificant, which excludes its enterohepatic circulation.

In the colon, sodium picosulfate is broken down to form the active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane. The time for development of the laxative effect of the drug is determined by the rate of release of the active metabolite and is 6-12 hours.

A small part of the drug enters the systemic circulation.

There is no relationship between the laxative effect of the active metabolite and its concentration in the blood serum.

Special instructions

Should not be used daily without medical supervision for more than 10 days.

Guttalax should be prescribed to children only on the recommendation of a doctor.

Active ingredient

Sodium picosulfate

Composition

Active ingredient:

sodium picosulfate 7.5 mg;

Excipients:

sodium methyl paraoxybenzoate;

sorbitol 70%;

hydrochloric acid;

purified water.

Contraindications

Increased sensitivity
intestinal obstruction
acute inflammatory diseases of the abdominal organs
abdominal pain of unknown origin
bleeding from the gastrointestinal tract.

Side Effects

Diarrhea, abdominal pain, dehydration, water and electrolyte imbalance, weakness, cramps, decreased blood pressure.

Interaction

With the simultaneous use of Guttalax and diuretics or corticosteroids, the risk of developing electrolyte disturbances increases.

Simultaneous administration of broad-spectrum antibiotics may reduce the laxative effect of Guttalax.

Overdose

Symptoms: Diarrhea, abdominal pain, dehydration, water and electrolyte imbalance, weakness, cramps, low blood pressure. In addition, with chronic overdose, ischemia of the colon mucosa, secondary hyperaldosteronism, urolithiasis, and damage to the renal tubules may develop.

Treatment: Gastric lavage, correction of water-electrolyte balance disorders, antispasmodics. Glucocorticosteroids and diuretics increase the risk of developing electrolyte disturbances.

Broad-spectrum antibiotics reduce the laxative effect.

Storage conditions

In a place protected from light, at a temperature not exceeding 25°C. Do not freeze.

Shelf life

5 years.

Manufacturer

Instituto de Angeli S.r.L., Italy