Groprinosin-Richter, 50 mg/ml syrup 150 ml
€19.34 €16.12
Pharmacotherapeutic group: immunostimulant.
ATX code: J05AX05
Pharmacodynamics
immunostimulant with antiviral effect. It is a complex containing inosine and para-acetamidobenzoic acid salt with N,N-dimethylamino-2-propanol in 1:3 molar ratio.
The effectiveness of the complex is determined by the presence of inosine, the second component increases its availability to lymphocytes. Inosin pranobex blocks the multiplication of viral particles by damaging the genetic apparatus, stimulates macrophage activity, lymphocyte proliferation and cytokine formation. The second component increases the availability of Groprinosin®-Richter to lymphocytes. It reduces clinical manifestations of viral diseases, accelerates recuperation, increases body resistance.
When administered as an adjunctive drug in infectious lesions of the mucous membranes and skin caused by Herpes simplex virus, the affected surface heals more quickly than with the traditional method of treatment. New blisters, swellings, erosions and recurrences of the disease occur less frequently. Timely use of the drug reduces the frequency of
viral infections, reduces the duration and severity of the disease.
Pharmacokinetics
After oral administration the drug is well absorbed from the gastrointestinal tract (GIT) and has good bioavailability. Maximum concentration of the ingredients in blood plasma is determined after 1-2 hours. It is rapidly metabolized and excreted through the kidneys. It is metabolized similarly to endogenous purine nucleotides with formation of uric acid. N,N-dimethylamino-2-propanol is metabolized to N-oxide, and 4-
acetamidobenzoate to o-acylglucuronide. No cumulation of the drug in the body has been detected. The elimination half-life (T1/2) is 3.5 h for N,N-dimethylamino-2-propanol and 50 min for 4-acetamidobenzoate. The drug and its metabolites are eliminated from the body by the kidneys within 24-48 hours.
Indications
– Treatment of influenza and other acute respiratory viral infections (ARI) as part of complex therapy.
– Treatment of labial herpes (Herpes simplex) as part of complex therapy
Active ingredient
Composition
1 ml of syrup contains:
Active substance:inosine pranobex – 50 mg.
Auxiliary substances: methylparahydroxybenzoate, propylparahydroxybenzoate, sucrose, sodium hydroxide, citric acid, water.
How to take, the dosage
Interaction
Immunosuppressants weaken the immunostimulatory effect of inosin pranobex. Inosin pranobex should be used with caution in patients taking simultaneously xanthine oxidase inhibitors (allopurinol) or drugs that can block the tubular secretion of uric acid, such as “loop” diuretics (furosemide, thorasemide, etacrynic acid), since this may lead to increased uric acid concentration in the blood serum.
Co-administration of inosine pranobex with zidovudine leads to an increase in plasma concentration of zidovudine and prolongs its elimination half-life. Thus, when co-administering inosin pranobex with zidovudine it may be necessary to adjust the dose of zidovudine prescribed by the physician.
If you are using the above medicinal products or other medicinal products (including over-the-counter medicinal products), consult your physician before using Groprinosin®-Richter.
Special Instructions
Inosin Pranobex, like other antiviral drugs, is most effective in acute viral infections if the treatment is started at an early stage of the disease (first day).
Since inosin is excreted from the body in the form of uric acid when prescribing Groprinosin®-Richter simultaneously with the drugs that increase uric acid concentration or with the drugs that impair kidney function it is necessary to monitor serum uric acid concentration.
Elderly patients are more likely than middle-aged patients to have increased concentrations of uric acid in serum and urine.
Patients with significantly elevated uric acid concentrations in the body may simultaneously take drugs that reduce its concentration.
Inosin pranobex should be used with caution in patients with acute hepatic impairment because the drug is metabolized in the liver.
Groprinosin®-Richter contains 650 mg of sucrose in 1 ml of syrup, which should be considered in patients with diabetes mellitus. The drug contains methyl parahydroxybenzoate and propyl parahydroxybenzoate, which may cause allergic reactions (possibly delayed). If any signs of allergy occur, discontinue the use of Groprinosin®-Richter and consult a physician.
Keep the instructions. You may need it again. If you have any questions, talk to your doctor.
Influence on ability to drive vehicles, machinery
The effect of inosin pranobex on psychomotor functions of the body and the ability to drive vehicles and moving mechanisms has not been studied. When using the drug, the possibility of dizziness and somnolence should be taken into account.
Synopsis
Contraindications
– Hypersensitivity to pranobex inosine and other components of the drug.
– Gout.
– Urinary stone disease.
– Arrhythmias.
– Chronic renal insufficiency.
– Under 3 years of age (body weight less than 15-20 kg).
– Pregnancy and lactation.
– Sugars/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
With caution
Caution should be exercised when concomitantly prescribed with xanthine oxidase inhibitors, diuretics, zidovudine, acute renal or hepatic failure, diabetes and long-term use of Groprinosin®-Richter.
If you are taking any of the above medicinal products or if you are suffering from any of the conditions described above, you should consult your doctor before using Groprinosin®-Richter.
Side effects
Overdose
Pregnancy use
Similarities
Weight | 0.342 kg |
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Shelf life | 2 years. Shelf life after opening the bottle – 6 months. Do not use after the expiration date shown on the package. |
Conditions of storage | At a temperature not exceeding 25 ° C. Keep out of reach of children. |
Manufacturer | Gedeon Richter Romania S.A., Romania |
Medication form | syrup |
Brand | Gedeon Richter Romania S.A. |
Other forms…
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