Gopanthenic acid, tablets 250 mg 50 pcs

Pharmacodynamics

The spectrum of action of gopanthenic acid is associated with the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action is due to the direct effect of the drug on GABA-brain receptor-channel complex.
Gopanthenic acid has nootropic and anticonvulsant effect.

The drug increases resistance of the brain to hypoxia and toxic substances, stimulates anabolic processes in neurons, combines a mild sedative effect with a mild stimulating effect, reduces motor excitability, stimulates mental and physical performance. It improves GABA metabolism in chronic alcohol intoxication and after ethanol withdrawal.

Gopanthenic acid is able to inhibit acetylation reactions that participate in procaine (novocaine) and sulfonamides inactivation mechanisms.

Gopantenic acid is quickly absorbed from the gastro-intestinal tract, penetrates through the blood-brain barrier and most concentrations are formed in the liver, kidneys, stomach wall and skin. The drug is not metabolized and is excreted unchanged within 48 hours: 67.5% of the taken dose – in the urine, 28.5% – in the feces.

Indications

Cognitive impairment in organic brain lesions, including the consequences of neuroinfections, traumatic brain injuries and neurotic disorders;
extrapyramidal hyperkinesis in patients with hereditary diseases of the nervous system in combination with ongoing therapy;
as a corrector for the side effects of neuroleptic drugs, for neuroleptic extrapyramidal syndrome (hyperkinetic and akinetic), as part of complex therapy for cerebral organic failure in patients with schizophrenia;
epilepsy with slowing of mental processes in complex therapy with anticonvulsants;
psycho-emotional overload, decreased mental and physical performance, to improve concentration and memory;
neurogenic urinary disorders (Pollakiuria, urgency, imperative urinary incontinence, enuresis);
children with developmental delays (mental, speech, motor, or a combination thereof), including those caused by perinatal encephalopathy and children with various forms of cerebral palsy;
children with hyperkinetic disorders (attention deficit hyperactivity disorder);
children with neurosis-like conditions (tics, stuttering, mainly in the clonic form).

Pharmacological effect

Pharmacodynamics

The spectrum of action of hopantenic acid is associated with the presence of gamma-aminobutyric acid (GABA) in its structure. The mechanism of action is due to the direct effect of the drug on the GABAB receptor-channel complex.
Hopanthenic acid has nootropic and anticonvulsant effects.

The drug increases the brain’s resistance to hypoxia and the effects of toxic substances, stimulates anabolic processes in neurons, combines a moderate sedative effect with a mild stimulating effect, reduces motor excitability, and activates mental and physical performance. Improves GABA metabolism during chronic alcohol intoxication and after ethanol withdrawal.

Hopantenic acid is capable of inhibiting acetylation reactions involved in the mechanisms of inactivation of procaine (novocaine) and sulfonamides, thereby prolonging the action of the latter. Causes inhibition of the pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

Hopanthenic acid is quickly absorbed from the gastrointestinal tract, penetrates the blood-brain barrier, the highest concentrations are created in the liver, kidneys, stomach wall and skin. The drug is not metabolized and is excreted unchanged within 48 hours: 67.5% of the dose taken is in the urine, 28.5% is in the feces.

Special instructions

In conditions of long-term treatment, simultaneous administration of the drug with other nootropic and stimulant drugs is not recommended.

In case of development of undesirable reactions, such as allergic rhinitis, conjunctivitis, allergic skin reactions, the drug must be discontinued. In case of development of adverse events from the central nervous system, it is necessary to reduce the dose of the drug.

Taking into account the nootropic effect of the drug, it is preferably taken in the morning and afternoon (up to 17:00).

Active ingredient

Hopantenic acid

Composition

Active ingredient:
calcium hopantenate (calcium salt of hopantenic acid) – 500.0 mg;
excipients:
magnesium hydroxycarbonate – 93.6 mg;
talc – 18.6 mg;
calcium stearate – 6.2 mg;
methylcellulose – 1.6 mg.

Pregnancy

The use of the drug during pregnancy and breastfeeding is not recommended due to the lack of experience in clinical use in this category of patients.

Contraindications

Hypersensitivity to hopantenic acid and other components of the drug;
acute severe kidney disease;
pregnancy;
breastfeeding period;
children up to 3 years old.

Side Effects

Classification of the incidence of side effects according to the recommendations of the World Health Organization (WHO):
very often ≥1/10;
often from ≥1/100 to <1/10;
uncommon ≥1/1000 to <1/100;
rarely from ≥1/10000 to <1/1000;
very rare <1/10000, including individual reports;
frequency unknown – based on available data, it is not possible to determine the frequency of occurrence.

Immune system disorders:
very rare: allergic reactions (rhinitis, conjunctivitis, allergic skin reactions).

Nervous system disorders:
very rarely: hyperexcitation, headache, dizziness, noise in the head.

Mental disorders:
very rarely: lethargy, lethargy, sleep disturbance, drowsiness.

If disorders of the immune system occur, the drug is discontinued. In other cases, reduce the dose of the drug.

Interaction

Prolongs the effect of barbiturates, enhances the effect of anticonvulsants, prevents the side effects of phenobarbital, carbamazepine, and neuroleptics. The effect of hopantenic acid is enhanced in combination with glycine and etidronic acid. Potentiates the effect of local anesthetics (procaine).

Overdose

In case of overdose, an increase in the severity of dose-dependent side effects is observed.
Symptoms:
Sleep disturbance or drowsiness, noise in the head.
Treatment:
Activated carbon, gastric lavage, symptomatic therapy.

Storage conditions

Store in a place protected from light at a temperature not exceeding 25 °C.
Keep out of the reach of children.

Shelf life

2 years.

Manufacturer

Ozon, Russia