Gopantam, tablets 250 mg 50 pcs

Gopantam is a nootropic, anticonvulsant.

Pharmacodynamics

It has neurometabolic, neuroprotective and neurotrophic properties. Increases resistance of the brain to hypoxia, stimulates anabolic processes in neurons, reduces motor excitability with simultaneous ordering of behavior. Increases mental and physical performance, reduces reactions to painful stimuli.

Pharmacokinetics

After oral administration it is quickly absorbed from the gastrointestinal tract. T_max is 1 h. It penetrates through the HEB. It is not metabolized. It is excreted unchanged in 48 hours in the urine (about 67%) and in the faeces (about 28%).

Indications

– cognitive impairment in organic brain lesions, including the consequences
neuroinfections, traumatic brain injuries and neurotic disorders;
– with extrapyramidal hyperkinesis, in patients with hereditary diseases of the nervous system in
combinations with ongoing therapy;
– as a corrector for side effects of neuroleptic drugs, for neuroleptic
extrapyramidal syndrome (hyperkinetic and akinetic), as part of complex therapy for
cerebral organic failure in patients with schizophrenia;
– epilepsy with slowing of mental processes in complex therapy with anticonvulsants;
– psycho-emotional overload, decreased mental and physical performance, to improve
concentration and memorization;
– neurogenic urinary disorders (pollakiuria, urgency, imperative incontinence
urine, enuresis);
– children with developmental delays (mental, speech, motor or a combination thereof), including those due to
suffered perinatal encephalopathy and in children with various forms of childhood cerebral
paralysis;
– children with hyperkinetic disorders (attention deficit hyperactivity disorder);
– children with neurosis-like conditions (tics; stuttering, mainly in the clonic form).

Pharmacological effect

Pharmacodynamics

The action of Gopantam® is associated with the presence of gamma-aminobutyric acid in the structure and its direct influence
on the GABA receptor-channel complex.
The drug has a nootropic and anticonvulsant effect. Increases brain resistance to hypoxia and
exposure to toxic substances, stimulates anabolic processes in neurons, combines moderate
sedative effect with a mild stimulating effect, reduces motor excitability,
activates mental and physical performance.
Improves the metabolism of gamma-aminobutyric acid in chronic alcohol intoxication and
subsequent withdrawal of ethanol.
Causes inhibition of the pathologically increased bladder reflex and detrusor tone.

Pharmacokinetics

After oral administration, it is quickly absorbed from the gastrointestinal tract. Highest concentrations
are created in the liver, kidneys, stomach wall and skin. Penetrates the blood-brain barrier. Not
metabolized. Excreted unchanged within 48 hours: 67.5% of the dose taken – c
urine, 28.5% – with feces.

Special instructions

In conditions of long-term treatment, simultaneous administration of the drug with other drugs is not recommended
nootropic and stimulant agents.
Use during pregnancy and breastfeeding
Use during pregnancy and breastfeeding is not recommended due to
lack of data on effectiveness and safety.
There is no information on the penetration of hopantenic acid into breast milk. If necessary
use of the drug during lactation, breastfeeding should be stopped.
Effect of the drug on the ability to drive vehicles and machinery
In the first days of taking the drug, you should be careful when driving vehicles
and mechanisms, taking into account the possible occurrence of drowsiness (see section “Side effects”).

Active ingredient

Hopantenic acid

Composition

Composition per tablet

Active ingredient:

calcium hopanthenate 250 mg 500 mg

Excipients:

magnesium carbonate (magnesium carbonate main) 33.0 mg 66.0 mg

talc 3.0 mg 6.0 mg

calcium stearate 9.0 mg 18.0 mg

methylcellulose 15.0 mg 30.0 mg

Tablet weight: 310.0 mg 620.0 mg

Contraindications

Hypersensitivity to any of the components of the drug, acute severe kidney disease,
pregnancy and breastfeeding, children under 3 years of age.

Side Effects

The incidence of side effects is classified according to the recommendations of the World Organization
healthcare: very often – at least 10%; often – not less than 1%, but less than 10%; infrequently – not less than 0.1%,
but less than 1%; rarely – not less than 0.01%, but less than 0.1%; very rarely (including isolated cases) – less
0.01%.

Immune system disorders: very rarely – allergic reactions (rhinitis, conjunctivitis,
skin allergic reactions). In this case, discontinue the drug.

Nervous system disorders: very rarely – hyperexcitation, sleep disturbance or drowsiness,
lethargy, lethargy, headache, dizziness, noise in the head. In this case, reduce the dose
drug.

Interaction

Prolongs the effect of barbiturates, enhances the effect of anticonvulsants, prevents
side effects of phenobarbital, carbamazepine, antipsychotics. Potentiates the effect of local
anesthetics (procaine).
The effect of Gopantam® is enhanced in combination with glycine and etidronic acid.

Overdose

Symptoms: sleep disturbance or drowsiness, noise in the head.
Treatment: activated carbon, gastric lavage, symptomatic therapy.

Storage conditions

In a dry place, protected from light

Shelf life

4 years. Do not use after expiration date.
Storage conditions
In a place protected from light at a temperature not exceeding 25 ºС.
Keep out of the reach of children.

Manufacturer

Altaivitamins, Russia