Glycerin, 40 g

Being an osmotically active compound, it increases osmotic pressure. After oral administration due to dehydrating effect it lowers intracranial pressure and intraocular pressure. When used rectally it has a mild irritating effect on the mucous membrane of the rectum and stimulates reflexively the contractility of the intestine, having a laxative effect, helps soften the feces and their passage through the large intestine. It has a soothing and dermatoprotective effect, has high hygroscopic and lubricating properties. When applied to the skin it activates its metabolic processes.

Indications

Orally – for dehydration therapy in cerebral edema caused by different reasons, before or after operations in ophthalmology (to reduce intraocular pressure), to stop an acute attack of glaucoma; rectally – with constipation of different genesis (functional, psychogenic, age), limitation of mobility, pregnancy and lactation, for prevention of constipation in patients who cannot strain when defecating (with painful, thrombosed hemorrhoids, perianal abscess, anorectal stenosis, after myocardial infarction); topically – to soften the skin and mucosa treatment. In pharmaceutical practice as a base for preparation of ointments and other dosage forms.

Active ingredient

Glycerol

Composition

Distilled glycerin – 1000 g; auxiliary substance – purified water to obtain glycerin with a density of 1.223-1.233.

Directions for use

As a laxative, it is used orally by 1-2 tablespoons per day, rectally – in enemas 2-5 ml once a day 15-20 minutes after breakfast. Treatment is discontinued after the restoration of normal peristalsis. Externally – treat skin and mucous membranes with a solution for external use.

Special Instructions

Regular use as a laxative is not recommended. When used systemically in dehydrated patients and in the presence of diabetes mellitus, there is an increased risk of developing symptoms of severe dehydration leading to vascular overload and, consequently, hyperglycemia. Nonketonergic hyperglycemic coma occurs quite rarely.

Contraindications

Hypersensitivity, renal failure, appendicitis, bleeding, diarrhea, hemorrhoids in the acute stage, anal fissures, inflammatory diseases and tumors of the rectum.

Side effects

Allergic reactions. With prolonged topical use – irritation and discomfort in the rectum, rarely – catarrhal proctitis.

Similarities

Glicelax