Glucosamine, 1500 mg 20 pcs

Remedy affecting the metabolism in the cartilage tissue. It replenishes the natural deficit of glucosamine, stimulates the synthesis of proteoglycans and hyaluronic acid synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage.

It promotes sulfur fixation in the synthesis of chondroitinous acid, facilitates normal calcium deposition in bone tissue, inhibits the development of degenerative processes in joints, restores their function and reduces pain.

Pharmacokinetics

Bioavailability of glucosamine during oral administration is 25% due to the effect of “first passage” through the liver. Highest concentrations of glucosamine are found in liver, kidney and joint cartilage. It is excreted mainly with urine unchanged, partially with feces. T1/2 is 68 h.

Indications

Primary and secondary osteoarthritis, glenohumeral periarthritis, osteochondrosis, spondylosis, chondromalacia of the patella.

Pharmacological effect

A drug that affects metabolism in cartilage tissue. Replenishes the natural deficiency of glucosamine, stimulates the synthesis of proteoglycans and hyaluronic acid in synovial fluid; increases the permeability of the joint capsule, restores enzymatic processes in the cells of the synovial membrane and articular cartilage.

Promotes fixation of sulfur in the process of chondroitinsulfuric acid synthesis, facilitates normal calcium deposition in bone tissue, inhibits the development of degenerative processes in joints, restores their function and reduces pain.

Pharmacokinetics

The bioavailability of glucosamine when taken orally is 25% due to the “first pass” effect through the liver. The highest concentrations of glucosamine are found in the liver, kidneys and articular cartilage. Excreted primarily in urine unchanged; partially – with feces. T1/2 is 68 hours.

Active ingredient

Glucosamine

Composition

1 pack (4 g).
glucosamine sulfate sodium chloride 1.884 g, which corresponds to the content of glucosamine sulfate 1.5 g.
Excipients:
sorbitol – 2081 mg,
citric acid monohydrate – 25 mg,
macrogol 4000 – 10 mg.

Pregnancy

Glucosamine is contraindicated for use during pregnancy and lactation (breastfeeding).

Contraindications

Hypersensitivity to glucosamine, phenylketonuria (if the drug contains aspartame), pregnancy, lactation.

Side Effects

Possible: pain in the epigastric region, nausea, flatulence, diarrhea, constipation, allergic reactions.

Interaction

When used in combination, glucosamine enhances the absorption of tetracyclines from the gastrointestinal tract and reduces the absorption of penicillins and chloramphenicol.

Recommendations for use

Take 1.5 g orally 1 time/day. The duration of treatment is usually 6 weeks, longer if necessary. Courses of treatment are usually repeated at intervals of 2 months.

Shelf life

3 years.

Manufacturer

Ozon, Russia