Glencet, 5 mg 10 pcs.

Glenzet is an enantiomer of cetirizine, a competitive histamine antagonist:

-blocks H1 -histamine receptors, the affinity for which is 2 times higher than that of cetirizine;

-affects the histamine-dependent stage of allergic reactions;

– reduces the migration of eosinophils;

– vascular permeability;

– limits the release of inflammatory mediators;

– prevents and eases the development of allergic reactions;

– has anti-exudative, antipruritic action;

– practically has no anticholinergic and antiserotonin action;

– in therapeutic doses, the sedative effect is very mild.

The action begins 12 minutes after a single dose in 50% of patients, after 1 hour in 95% of patients and lasts for 24 hours.

Indications

Symptomatic treatment of year-round and seasonal allergic rhinitis and allergic conjunctivitis (sneezing, rhinorrhea, lacrimation, conjunctival hyperemia), hay fever, urticaria (including chronic idiopathic, Quincke’s edema) and other allergic dermatoses accompanied by itching and rashes.

Pharmacological effect

Glencet is an enantiomer of cetirizine, a competitive histamine antagonist:

– blocks H1-histamine receptors, the affinity for which is 2 times higher than that of cetirizine;

– influences the histamine-dependent stage of allergic reactions;

– reduces the migration of eosinophils;

– vascular permeability;

– limits the release of inflammatory mediators;

– prevents the development and facilitates the course of allergic reactions;

– has an antiexudative, antipruritic effect;

– has virtually no anticholinergic and antiserotonin effects;

– in therapeutic doses the sedative effect is very weak.

The action begins 12 minutes after taking a single dose in 50% of patients, after 1 hour in 95%, and continues for 24 hours.

Active ingredient

Levocetirizine

Composition

Active ingredient:

Levocetirizine dihydrochloride 5 mg

Excipients:

Lactose monohydrate (Tablettose 100)

Microcrystalline cellulose (Avicel RN 112)

Colloidal silicon dioxide (Aerosil 200)

Magnesium stearate

Opadry white

Contraindications

Hypersensitivity, incl. to piperazine derivatives, severe chronic renal failure (Cl creatinine

Side Effects

Headache, drowsiness, dry mouth, fatigue;

rarely – migraine, dizziness, dyspeptic symptoms, allergic reactions (angioedema, rash, urticaria, itching).

Interaction

Theophylline (400 mg/day) reduces the total clearance of levocetirizine by 16%, while the kinetics of theophylline does not change.

Combined use with macrolides or ketoconazole did not cause significant changes in the ECG.

May enhance the effects of CNS depressants and ethanol.

Overdose

Symptoms: drowsiness, in children – anxiety, irritability.

Treatment: gastric lavage, activated carbon, symptomatic therapy.

There is no specific antidote.

Hemodialysis is ineffective.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30 °C

Shelf life

3 years

Manufacturer

Glenmark Pharmaceuticals Ltd, India