Glenzet is an enantiomer of cetirizine, a competitive histamine antagonist:
-blocks H1 -histamine receptors, the affinity for which is 2 times higher than that of cetirizine;
-affects the histamine-dependent stage of allergic reactions;
– reduces the migration of eosinophils;
– vascular permeability;
– limits the release of inflammatory mediators;
– prevents and eases the development of allergic reactions;
– has anti-exudative, antipruritic action;
– practically has no anticholinergic and antiserotonin action;
– in therapeutic doses, the sedative effect is very mild.
The action begins 12 minutes after a single dose in 50% of patients, after 1 hour in 95% of patients and lasts for 24 hours.
Increased lacrimation, Dermatosis, Sneezing, Allergic conjunctivitis, Neurodermitis, Urticaria, Skin itching, Allergy, Runny nose (rhinitis), Pollinosis
Symptomatic treatment of year-round and seasonal allergic rhinitis and allergic conjunctivitis (sneezing, rhinorrhea, lacrimation, conjunctival hyperemia), pollinosis, urticaria (incl.including chronic idiopathic, Quincke’s edema) and other allergic dermatoses accompanied by itching and rashes.
Levocetirizine dihydrochloride 5 mg
Lactose monohydrate (Tabletose 100)
Microcrystalline cellulose (Avicel PH 112)
Colloidal silicon dioxide (Aerosil 200)
How to take, the dosage
Overly, with meals or on an empty stomach, with a small amount of water, without chewing.
The recommended dosage for adults and children over 6 years of age, and for elderly patients (if renal function is normal) is 5 mg (1 tablet) once daily.
In patients with chronic renal failure, the dose is reduced 2-fold (1 tablet every other day) in patients with a CK of 30 to 49 ml/min and 3-fold (1 tablet every 3 days) in patients with a CK of 10 to 29 ml/min.
Patients with hepatic impairment do not require dosing adjustments.
The course of treatment in chronic diseases is up to 18 months.
Theophylline (400 mg/day) decreases total clearance of levocetirizine by 16%, while the kinetics of theophylline is not changed.
The co-administration with macrolides or ketoconazole did not cause significant changes in ECG.
It may increase the effect of CNS depressants and ethanol.
Hypersensitivity, including to piperazine derivatives, severe chronic renal failure (creatinine Cl
Headache, drowsiness, dry mouth, fatigue;
rarely, migraine, dizziness, dyspeptic symptoms, allergic reactions (angioedema, rash, urticaria, itching).
Symptoms: drowsiness, in children – anxiety, irritability.
Treatment: gastric lavage, activated charcoal, symptomatic therapy.
There is no specific antidote.
Hemodialysis is ineffective.
Xizal, Suprastinex, Glencet, Elcet, Levocetirizine tablets, Allerwei, Levocetirizine
|Conditions of storage|
In a dry, light-protected place at a temperature not exceeding 30 °C
Glenmark Pharmaceuticals Ltd, India
Glenmark Pharmaceuticals Ltd
Buy Glencet, 5 mg 10 pcs. with delivery to USA, UK, Europe and over 120 other countries.