Gastrostat, 100 mg 90 pcs.
Out of stock
(E-mail when Stock is available)
Pharmacotherapeutic group: gastroprotective agent.
The ATX code: A02BX14
Rebampid increases prostaglandin E2 (PGE2) content in gastric mucosa and increases PGE2 and GI2 content in gastric juice content. It has cytoprotective effect on the gastric mucosa under the damaging effects of ethanol, acids and alkalis, acetylsalicylic acid.
It promotes the activation of enzymes that accelerate the biosynthesis of high-molecular-weight glycoproteins, and increases the content of mucus on the surface of the gastric wall.
Helps improve the blood supply to the gastric mucosa, activates its barrier function, activates alkaline secretion of the stomach, increases the proliferation and metabolism of gastric epithelial cells, cleanses the mucosa of hydroxyl radicals and suppresses superoxides, produced by polymorphonuclear leukocytes and neutrophils in the presence of Helicobacter pylori, protects gastric mucosa from bacterial damage, has gastroprotective effect when the mucosa is affected by non-steroidal anti-inflammatory drugs (NSAIDs).
Absorption when taken orally is high. After administration at a dose of 100 mg, the peak plasma concentration (Cmax) is reached after approximately 2 hours and is 340 ng/ml. The elimination half-life (T1/2) is approximately 1.0 h. Repeated administration of the drug does not cause its cumulation in the body.
About 10% of the drug is excreted by the kidneys, mostly unchanged. When taken in a dose of 600 mg, traces of the hydroxylated metabolite can be excreted.
In in vitro experiments it has been shown that 98.4% to 98.6% of the drug is bound to plasma proteins.
Gastric ulcer. Chronic gastritis with increased acid-forming function of the stomach in the acute stage, erosive gastritis. Prevention of mucosal damage against the background of taking nonsteroidal anti-inflammatory drugs. Can be used as part of combination therapy.
1 film-coated tablet contains:
acting substance:rebampid – 100 mg.
Excipients: magnesium carbonate, hypromellose (hydroxypropyl methylcell lulose), collidone XL F, sodium lauryl sulfate, citric acid, magnesium stearate.
Shell excipients:hypromellose (hydroxypropyl methylcellulose), macrogol 6000 (polyethylene glycol 6000), titanium dioxide, talc.
How to take, the dosage
Orally, 1 tablet 3 times a day with plenty of fluid. The course of treatment is 2-4 weeks, if necessary it can be prolonged up to 8 weeks. The drug has no peculiarities of action at the first administration or at its cancellation.
If you miss one dose, take the next dose of the drug at the prescribed time, you should not take a double dose of the drug.
When rebamipide is used as part of traditional therapy regimens of patients with Helicobacter pylori infection, the efficacy of eradication therapy increases significantly. Interaction reactions with other drugs have not been studied.
Impact on the ability to drive vehicles, mechanisms
The effect of the drug on the speed of psychomotor reactions and/or the ability to operate vehicles or mechanisms has not been studied. Driving and other activities requiring increased concentration should be treated with caution when taking the drug.
Round biconvex film-coated tablets, white or almost white. On the cross section the core is white or almost white.
Individual intolerance to rebampide or other components of the drug.
Children under 18 years of age.
Cautions are recommended when first prescribing rebampide to elderly patients due to the possibility of hypersensitivity to the drug.
Gastrointestinal tract: constipation, flatulence, diarrhea, nausea, vomiting, abdominal pain, taste disorders, heartburn.
Liver disorders: signs of liver dysfunction, increased serum glutamine alanine aminotransferase (ALT) and serum glutamine aspartate aminotransferase (AST).
Hematopoietic system disorders: leukopenia, granulocytopenia.
Allergic reactions: itching, skin rash, eczematous rash.
Other: menstrual disorders.
Symptoms of rebamipide overdose are not described, no cases of intentional overdose have been reported to date. Nausea, vomiting, abdominal pain, diarrhea or constipation, headache are possible.
Care measures: A specific antidote is not known. In case of overdose, gastric lavage and symptomatic therapy should be carried out.
The safety of rebamipide administration during pregnancy has not been proven. Do not use during pregnancy. Since rebamipide penetrates into the breast milk, breastfeeding should be stopped or artificial feeding of the child should be considered if it is necessary to prescribe rebamipide to the mother during breastfeeding.
Rebamipid , Rebagit
3 years. Do not use after the expiration date.
|Conditions of storage|
At a temperature not higher than 25 ° C. Keep out of reach of children.
Alium JSC, Russia
Buy Gastrostat, 100 mg 90 pcs. with delivery to USA, UK, Europe and over 120 other countries.