Galavit, rectal, 100 mg 10 pcs

Pharmacotherapeutic group:

An immunomodulatory and anti-inflammatory agent.

TAC code: L03, G02.

Pharmacological properties:

Pharmacodynamics

The mechanism of action of the drug is associated with its ability to regulate

the functional and metabolic activity of cells of innate and adaptive immunity (monocytes, macrophages, neutrophils, natural killers, etc.). Galavit normalizes phagocytic activity of monocytes/ macrophages, bactericidal activity of neutrophils and cytotoxic activity of NK-cells.

With this, by restoring reduced activity of cells of innate and adaptive immunity, the preparation increases resistance of the body to infectious diseases.

In addition Galavit normalizes antibody formation and increases functional activity (affinity) of antibodies.

In case of inflammatory diseases the preparation reversibly inhibits for 6-8 hours the excessive synthesis by hyperactivated macrophages of tumor necrosis factor-α, interleukin-1, interleukin-6 and other pro-inflammatory cytokines the level of which determines the degree of inflammatory reactions, their

cyclic activity as well as the severity of intoxication of the body. Galavit decreases the production of reactive oxygen species by hyperactivated macrophages, thus reducing the level of oxidative stress and protecting tissues and organs from the damaging effects of radicals.

The drug has no allergizing, mutagenic, embryotoxic, teratogenic and carcinogenic action.

Pharmacokinetics

Extracted from the body mainly through the kidneys. After rectal administration

The elimination half-life is 40-60 minutes. The main pharmacological effects are observed within 72 hours. Aminodihydrophthalazindione sodium in suppositories when administered rectally has high bioavailability, due to which both local and expressed systemic effects are achieved.

Indications

As an immunomodulatory and anti-inflammatory agent in the treatment of immunodeficiency disorders in adults and adolescents over 12 years:

– infectious and inflammatory urogenital diseases (urethritis of chlamydial and trichomonadic etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, endometritis);

– pelvic inflammatory diseases;

– chronic recurrent disease caused by the herpes virus;

– disease caused by the papilloma virus;

– Postoperative rehabilitation of patients with uterine myoma;

– complications of postoperative period in women of reproductive age;

–

Postoperative septic complications and their prevention (including those in cancer patients);

Chronic recurrent furunculosis, rust;

Nonspecific prevention and treatment of influenza and acute respiratory infections.

– inflammatory diseases of the mucous membranes of the mouth and throat,

Parodontal diseases;

– viral hepatitis;

– infectious intestinal diseases with intoxication and/or diarrhea;

– gastric and 12 duodenal ulcer;

– asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including athletes); mental, behavioral and postabstinence disorders with alcohol and drug abuse.

Active ingredient

Composition

Active ingredient:

Sodium aminodihydrophthalazindione (Galavit®) – 100 mg;

Auxiliary substances:

vitepsol W-35 (fatty acid glycerides) – 575 mg,

vitepsol H-15 (fatty acid glycerides) – 575 mg.

How to take, the dosage

Rectally. The suppository is freed from the contoured package and then inserted into the rectum. It is recommended to free the intestine beforehand.

The dose and duration of use of the drug depends on the nature, severity and duration of the disease.

– In urogenital diseases – urethritis of chlamydial and trichomonadic aetiology, chlamydial prostatitis: 1 day 1 suppository twice, then one every other day. The course of 10-15 suppositories (depending on the severity of the pathological process).

– In salpingo-oophoritis, endometritis in the acute period: 2 days of 2 suppositories once a day, then one suppository at intervals of 72 hours. In the chronic period: 5 days with 1 suppository once a day, then one suppository every 72 hours. The course is 20 suppositories.

– In acute and chronic purulent diseases of the pelvic organs – in the acute period: 1 day 2 suppositories once, 3 days one suppository daily, then one every other day for 5 days. The course of 10 suppositories. In the chronic period: 5 days 1 suppository once daily, then one every 72 hours. The course is 20 suppositories.

– In chronic relapsing diseases caused by the herpes virus: 1 suppository daily 5 suppositories, then 1 suppository every other day – 15 suppositories.

– In diseases caused by the papilloma virus: 5 days 1 suppository once a day, then 1 suppository every other day. The course is 20 suppositories.

– For postoperative rehabilitation of patients with uterine myoma and complications of the postoperative period in women of reproductive age: 5 days with 1 suppository once a day, then one suppository every other day. The course is 15 suppositories.

– For prevention and treatment of surgical complications in pre- and postoperative period (including cancer patients): 1 suppository 1 time daily – 5 suppositories before surgery, 5 suppositories after surgery – 1 every other day and 5 suppositories – with interval of 72 hours. If the course of the disease is severe, the initial dose is 2 suppositories once or twice a day with one suppository. The course of treatment is 20 suppositories.

Interaction

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use