Gabapentin, capsules 300 mg 50 pcs

Monotherapy or as adjunctive treatment for partial seizures with or without secondary generalization in adults and children from 12 years of age;

Neuropathic pain in adults (18 years and older).

Indications

Monotherapy or as adjunctive treatment for partial seizures with or without secondary generalization in adults and children from 12 years of age;

Neuropathic pain in adults (18 years and older).

Active ingredient

Composition

1 capsulabapentin 300 mg

Associated substances:

calcium stearate – 4.2 mg,

sodium carboxymethyl starch (type A) – 4.2 mg,

cellulose microcrystalline – 111.6 mg.

How to take, the dosage

Over the body, swallowed whole, regardless of meals, with plenty of fluids. If it is necessary to reduce the dose, stop the medicine, or replace it with an alternative medicine, this should be done gradually over at least one week.

Neuropathic pain in adults

The initial daily dose is 900 mg divided into three doses; if necessary, the dose is gradually increased to a maximum of 3600 mg/day. Treatment may begin immediately with a dose of 900 mg/day (300 mg three times daily) or the dose may be increased gradually to 900 mg daily for the first 3 days according to the following schedule:

Day 1: 300 mg once daily;

Day 2: 300 mg 2 times daily;

Day 3: 300 mg 3 times daily.

Partial seizures

Adults and children over 12 years of age: effective dose is 900 to 2400 mg/day. Therapy may be started with a dose of 300 mg 3 times daily on the first day or increased gradually to 900 mg according to the scheme described above. Subsequently, the dose may be increased to a maximum of 3600 mg/day (divided into 3 equal doses). The maximum interval between doses at three doses of the drug should not exceed 12 hours in order to avoid recurrence of seizures.

Matching doses in renal failure

Patients with renal impairment are recommended to reduce the dose of Gabapentin according to the table:

Creatinine clearanceDaily dose (mg/day)>80900-240050-79600-1200-1230-49300-60015-29150*-300150*

* administer 300 mg every other day

Recommendations for patients on hemodialysis

Patients on hemodialysis who have not previously taken Gabapentin are advised to prescribe a saturation dose of 300-400 mg and then use 200-300 mg every 4 hours of hemodialysis.

Interaction

Morphine: when Gabapentin and morphine were coadministered, when morphine was taken 2 hours before Gabapentin administration, a 44% increase in the mean area under the pharmacokinetic AUC of Gabapentin was observed compared to Gabapentin monotherapy, which was associated with an increase in pain threshold (cold pressor test). The clinical significance of this change has not been established, and the pharmacokinetic characteristics of morphine were not altered. Side effects of morphine combined with Gabapentin did not differ from those of morphine combined with placebo. No interaction between Gabapentin and phenobarbital, phenytoin, valproic acid and carbamazepine was noted. Pharmacokinetics of Gabapentin in equilibrium is similar in healthy people and patients receiving other anticonvulsants.

The concomitant use of Gabapentin with oral contraceptives containing norethisterone and/or ethinylestradiol was not accompanied by changes in pharmacokinetics of both components.

The concomitant use of Gabapentin with antacids containing aluminum and magnesium is accompanied by a decrease in the bioavailability of Gabapentin by approximately 20%. It is recommended to take Gabapentin about 2 hours after taking an antacid.

Probenecid has no effect on the renal excretion of Gabapentin.

A slight decrease in renal excretion of Gabapentin when concomitantly taking cimetidine is probably not clinically relevant.

Contraindications

– hypersensitivity to any of the ingredients of the drug,

– age under 12 years for partial convulsions.

With caution: renal failure.

Side effects

In the treatment of neuropathic pain

The body in general: accidental injury, asthenia, back pain, flu-like syndrome, headache, infection, pain of various localization, peripheral edema, weight gain;

The digestive tract: constipation, diarrhea, dry mouth, dyspepsia, flatulence, nausea, vomiting, abdominal pain;

Nervous system: gait disturbance, amnesia, ataxia, confusion, dizziness, hypoesthesia, somnolence, impaired thinking, tremor;

Respiratory system: shortness of breath, pharyngitis;

Skin and subcutaneous tissue: skin rash;

Sensory organs: amblyopia.

In treatment of partial seizures

The body as a whole: back pain, fatigue, fever, headache, viral infection, peripheral edema, weight gain, asthenia,-general malaise, facial edema;

The cardiovascular system: symptoms of vasodilation or hypertension;

Digestive tract: constipation, dental disease, diarrhea, dyspepsia, increased appetite, dry mouth or throat, nausea and/or vomiting, abdominal pain, flatulence, anorexia, gingivitis;

The blood, lymphatic system: Leukopenia, purpura (most commonly described as bruising from physical trauma);

Bone and muscular system: fractures, myalgias, arthralgias;

Nervous system: amnesia, ataxia, confusion, impaired coordination, depression, dysarthria, emotional lability, insomnia, nervousness, nystagmus, somnolence, thought disorder, tremor, muscle twitching, vertigo, hyperkinesis; increased, weakened or absent reflexes, paresthesias, anxiety, hostility;

The respiratory system: cough, pharyngitis, rhinitis, pneumonia;

Skin and subcutaneous tissues: abrasions, windows, itchy skin, skin rash;

Sensory organs: amblyopia, diplopia, visual disturbances;

The urinary system: urinary tract infection, impotence.

Overdose

Symptoms: dizziness, double vision, speech disorders, drowsiness, lethargy, diarrhea.

Treatment: gastric lavage, intake of activated charcoal, symptomatic therapy. Patients with severe renal failure may be indicated for hemodialysis.

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