Furagin, tablets 50 mg 10 pcs

Pharmacodynamics

An antimicrobial agent, nitrofuran derivative. Effective against Gram-positive cocci (Staphylococcus spp., Streptococcus spp.), Gram-negative bacilli (Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.). Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., most strains of Proteus spp., Serratia spp. are resistant. Furazidine is reduced by bacterial flavoproteins to active compounds that inactivate or damage proteins of bacterial ribosomes and other macromolecules.

As a result, aerobic respiration and processes of protein, cell wall, DNA and RNA synthesis are disrupted. Multiple mechanism of action explains weak acquired resistance of microorganisms to nitrofurans. Depending on the concentration, it has a bactericidal or bacteriostatic effect. Against most of the bacteria the bacteriostatic concentration is from 10 to 20 µg/ml.

The bactericidal concentration is about 2 times higher. As a result of the action of nitrofurans, microorganisms release fewer toxins, due to which improvement of the general state of the patient is possible even before pronounced suppression of microflora growth.

Pharmacokinetics

Absorption – in the small intestine, by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds absorption from the proximal and medial segments by 2 and 4 times respectively (should be considered in the treatment of diseases of the urinary tract in combination with diseases of the gastrointestinal tract, including chronic enteritis).

It is poorly absorbed in the colon. It is distributed evenly. In high concentrations it is found in lymph; in bile its concentration is several times higher than in serum, in cerebrospinal fluid – several times lower than in serum; in saliva it contains up to 30% of the concentration in serum; in blood and tissues its concentration is low, which is due to its rapid excretion, while its concentration in urine is much higher than in blood.

The maximum concentration (Cmax) in blood serum lasts from 3 to 7-8 hours, in the urine it is detected after 3-4 hours. It does not change pH of urine in contrast to nitrofurantoin. It is metabolized in liver (less than 10%), intensity of metabolism increases when renal excretory function decreases.

Extracted by the kidneys by glomerular filtration and tubular secretion (85%), partially reabsorbed in the tubules. At low concentrations in the urine the filtration and secretion process prevails, at high concentrations the secretion decreases and the reabsorption increases. Being a weak acid it does not dissociate at acidic pH values of urine, it undergoes intense reabsorption, which may increase the systemic side effects.

Indications

Inflammation of the female genitals, Urethritis, Urinary tract infectionsInfectious and inflammatory diseases: urinary tract (cystitis, urethritis, pyelonephritis); female genital infections; prevention of infections during urological surgeries, cystoscopy, catheterization.

Active ingredient

Furazidine

How to take, the dosage

Furagin is taken orally, after meals – 50-100 mg 3 times a day for 7-10 days. If necessary, the second course of treatment may be carried out after 10-15 days, for prevention of infection during urological surgeries, cystoscopy, catheterization take 50 mg once 30 minutes before surgery or manipulation.

Interaction

Concomitant use with ristomycin, chloramphenicol, sulfonamides increases the risk of hematotoxic effect. Concomitant use of other nitrofuran derivatives as well as drugs that “acidify” the urine (including ascorbic acid, calcium chloride) should be avoided. Ethanol may increase the severity of side effects.

Probenecid and sulfinpyrazone decrease excretion of furazidine in the urine. This may lead to cumulation of furazidine and increase its toxicity.

Simultaneous use of magnesium-containing antacids reduces absorption of furazidine.

Special Instructions

A lot of drinking is prescribed to prevent the development of side effects. B-group vitamins should be prescribed to prevent the development of neuritis.
Long-term use requires monitoring of peripheral blood count, kidney and liver function, lung function.

Possible false-positive results in determining glucose in urine by enzymatic methods.
Taking into account the possible side effects of the drug on the nervous system during its use it is necessary to be careful when performing potentially dangerous activities requiring increased concentration and quick psychomotor reactions.

Impact on the ability to operate vehicles, machinery.

In view of the side effects of the drug, you should refrain from performing the above activities.

Contraindications

• High sensitivity to furazidine, other drug components
• High sensitivity to nitrofuran derivatives
• Kidney function impairment
• Liver function impairment;
• deficiency of lactase, sugar/isomaltose, lactose intolerance, fructose, glucose-galactose malabsorption;
• pregnancy;
• pregnancy;
• children under 18 years of age.

Furazidine is not recommended for urosepsis and renal parenchyma infections.