Fortrans, 64 g 4 pcs

Pharmacodynamics

Fortrans® is an osmotic laxative containing Macrogol 4000 (polyethylene glycol) and electrolytes (sodium, potassium, bicarbonate and chlorides).

Macrogol 4000 high molecular weight compound is a long linear polymers capable of holding water molecules with the help of hydrogen bonds. After oral administration the compound increases the volume of liquid in the intestine. The volume of liquid unabsorbed in intestine ensures the laxative effect of the drug solution.

The electrolytes contained in the drug ensure maintenance of the blood plasma composition. The concentration of electrolytes in Fortranz® solution is such that electrolyte exchange between intestinal contents and blood plasma is practically reduced to zero. Thus the presence of electrolytes in Fortranz® preparation prevents their loss from the body during large amount of fluid passing through the gastrointestinal tract during drug administration.

Pharmacokinetics

The solution prepared by dissolving 1 sachet of the preparation in 1 liter of water is isotonic and isoosmotic to the large intestine.

The results of pharmacokinetic studies confirm the absence of absorption and biotransformation of Macrogol 4000 after oral administration.

Indications

Colon cleansing when preparing a patient for the following procedures: endoscopic or radiological examination of the colon; surgical procedures requiring the absence of contents in the colon.

Active ingredient

How to take, the dosage

Interaction

Special Instructions

Persons of advanced age with poor health are advised to use the drug only under the supervision of medical personnel.

The intake of solid foods should be avoided for at least two hours before administration of Fortrans® and until the end of the examination. Drinks such as tea, coffee (without milk) and other non-alcoholic beverages are allowed.

The patient must maintain an interval of at least 1 hour between taking Fortrans® and other medications.

The drug contains Macrogol 4000 (polyethylene glycol). Allergic reactions (anaphylactic shock, angioedema, urticaria, skin rash) have been reported after administration of preparations containing polyethylene glycol.

Persons with inflammation of the intestinal mucosa, including the rectum, should be cautioned when prescribing Fortrans®.

The product should be used with caution and only under the care of medical personnel in patients who are prone to aspiration, in bed-ridden patients, in patients with neurologic disorders and/or in patients with impaired motor function because of the risk of aspiration pneumonia. In such patients the drug is administered in a sitting position and through a nasogastric tube.

Patients who are semi/conscious should be monitored closely during the administration of the drug. If symptoms of abdominal pain or bloating occur, the rate of administration should be reduced or administration should be suspended until these symptoms disappear.

Because of the isotonic composition of Fortrans®, patients are not expected to have electrolyte imbalances after administration, except in patients at risk of electrolyte and water imbalances. Patients with water-electrolyte imbalances should receive appropriate therapy for their elimination prior to the bowel cleansing procedure.

The drug should be used with caution in patients who are prone to develop a water-electrolyte imbalance, including hyponatremia and hypokalemia, as well as in patients who have a higher risk of side effects (patients with impaired renal function, with heart failure or in patients with concomitant diuretic therapy). The use of the drug in these patients should be closely monitored.

Particular caution should be exercised in patients with cardiac and renal insufficiency because of fluid overloading they are at risk of acute pulmonary edema. The experience of using the drug in patients with impaired renal function is limited.
The effectiveness and safety of the drug Fortrans® in children under 18 years old has not been established.

Contraindications

Side effects

Overdose

Pregnancy use

Similarities