Forliver Help, tablets 100 mg 30 pcs

The main active component of the drug is the sum of flavolignans (silymarin) derived from fruits of milk thistle Silybum marianum (L.) Gaerth of Asteraceae (including silybinin, isosilibinin, silydianin, silicristin).

Pharmacodynamics

The drug has hepatoprotective and antitoxic effect. The therapeutic effect is due to the effect on hepatocyte metabolism. It activates synthesis of proteins and enzymes in hepatocytes, stabilizes the membrane of hepatocytes, inhibits penetration of toxins into liver cells, inhibits dystrophic and potentiates regenerative processes of the liver.

Pharmacokinetics

The adsorption of silibinin is quite low and only 2-3% is excreted with bile during the first 24 hours. As a result of cleavage by the intestinal microflora, up to 40% of the silibinin excreted with bile is reabsorbed, resulting in entero-hepatic circulation. The peak of silybinin in plasma after oral administration is reached after 3-4 hours. Silymarin is eliminated from the body mainly with the bile and, to a lesser extent, by the kidneys. The half-life is 6 to 8 hours. It does not accumulate in the body.

Indications

Taken for toxic liver damage, chronic hepatitis, liver cirrhosis (as part of complex therapy), after hepatitis. Prophylactically, used for chronic intoxication (including occupational), long-term use of medications and alcohol.

Pharmacological effect

The main active component of the drug is the amount of flavolignans (silymarin) obtained from the fruits of milk thistle Silybum marianum (L.) Gaerth family. Asteraceae – Asteraceae (including silibinin, isosilibinin, silydianin, silicristin).

Pharmacodynamics

The drug has hepatoprotective and antitoxic effects. The therapeutic effect is due to the effect on the metabolism of hepatocytes. Activates the synthesis of proteins and enzymes in hepatocytes, has a stabilizing effect on the hepatocyte membrane, inhibits the penetration of toxins into liver cells, inhibits dystrophic and potentiates regenerative processes of the liver.

Pharmacokinetics

The adsorption of silibinin is quite low and only 2-3% is excreted in the bile during the first 24 hours. As a result of breakdown by intestinal microflora, up to 40% of silibinin released in bile is reabsorbed, resulting in enterohepatic circulation. The peak of silibinin in plasma after oral administration is reached within 3-4 hours. Silymarin is excreted from the body primarily through bile and, to a lesser extent, through the kidneys. The half-life is from 6 to 8 hours. Does not accumulate in the body.

Special instructions

The drug is used as prescribed by a doctor.
Patients with diabetes mellitus should take into account that the carbohydrate content in a single dose of the drug (1 tablet) corresponds to 0.0082 XE, in the maximum daily dose of the drug (6 tablets) – 0.0492 XE.

Impact on the ability to drive vehicles and machinery

The use of the drug does not affect the ability to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher, operator).

Active ingredient

Milk thistle fruit extract

Composition

For 1 tablet:
active substance:
Milk thistle fruit extract dry (Silymarin extract dry) (containing the sum of flavolignans in terms of silybin at least 65%) – 100.0 mg.
excipients:
lactose monohydrate – 50.0 mg,
potato starch – 48.0 mg,
magnesium stearate – 2.0 mg.

Pregnancy

The use of the drug during pregnancy and breastfeeding is contraindicated (due to the lack of data on the effectiveness and safety of use in this category of patients).

Contraindications

Individual intolerance, hypersensitivity to the components of the drug, pregnancy, breastfeeding, children under 12 years of age, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.

With caution

Patients with diabetes mellitus, children over 12 years of age.

Side Effects

Allergic reactions are possible, in some cases a laxative effect. If side effects not described in these instructions occur, you should stop taking the drug and inform your doctor.

Interaction

When used together with oral contraceptives and drugs used in hormone replacement therapy, the effects of the latter may be reduced. The drug can enhance the effects of drugs such as diazepam, alprozolam, ketoconazole, lovastatin, vinblastine due to its suppressive effect on the cytochrome P450 isoenzyme system.

Overdose

To date, no cases of overdose have been registered. If you take a dose several times higher than the therapeutic dose, you should induce vomiting and rinse the stomach, then take activated charcoal, and, if necessary, undergo symptomatic treatment.

Storage conditions

At a temperature not exceeding 25°C, in the original packaging.
Keep out of the reach of children.

Shelf life

5 years.

Manufacturer

PharmVilar NPO LLC, Russia