Forliver Help, tablets 100 mg 30 pcs
€10.73 €9.39
The main active component of the drug is the sum of flavolignans (silymarin) derived from fruits of milk thistle Silybum marianum (L.) Gaerth of Asteraceae (including silybinin, isosilibinin, silydianin, silicristin).
Pharmacodynamics
The drug has hepatoprotective and antitoxic effect. The therapeutic effect is due to the effect on hepatocyte metabolism. It activates synthesis of proteins and enzymes in hepatocytes, stabilizes the membrane of hepatocytes, inhibits penetration of toxins into liver cells, inhibits dystrophic and potentiates regenerative processes of the liver.
Pharmacokinetics
The adsorption of silibinin is quite low and only 2-3% is excreted with bile during the first 24 hours. As a result of cleavage by the intestinal microflora, up to 40% of the silibinin excreted with bile is reabsorbed, resulting in entero-hepatic circulation. The peak of silybinin in plasma after oral administration is reached after 3-4 hours. Silymarin is eliminated from the body mainly with the bile and, to a lesser extent, by the kidneys. The half-life is 6 to 8 hours. It does not accumulate in the body.
Indications
Take in toxic damage to the liver, chronic hepatitis, cirrhosis (in the complex therapy), after hepatitis. Prophylactically, used in chronic intoxication (including occupational), prolonged intake of drugs and alcohol.
Active ingredient
Milk thistle fruit extract
Composition
There are 1 tablet:
active ingredient:
milk thistle fruit extract dry (Silymarin extract dry) (with the content of the amount of flavolignans in terms of silybin at least 65%) -100.0 mg.
excipients:
lactose monohydrate – 50.0 mg,
potato starch – 48.0 mg,
magnesium stearate – 2.0 mg.
How to take, the dosage
Used in adults and children over 12 years of age orally 1 to 2 tablets 3 times a day for 30 minutes before a meal. The course of treatment 25 – 30 days. In chronic diseases it is advisable to repeat the course of treatment in 1-3 months.
If the drug was missed or insufficient amount was taken, the subsequent administration should be carried out as specified in these instructions, without any changes.
Interaction
When concomitant use of the drug with oral contraceptives and drugs used in hormonal replacement therapy, the effects of the latter may be reduced. The drug may increase the effects of such drugs as diazepam, alprozolam, ketoconazole, lovastatin, vinblastine due to its inhibitory effect on the cytochrome P450 isoenzyme system.
Special Instructions
The preparation is administered according to the prescription of the physician.
Patients with diabetes mellitus should know that carbohydrate content in a single dose of the preparation (1 tablet) is 0.0082 ХU, in the maximum daily dose of the preparation (6 tablets) – 0.0492 ХU.
Impact on ability to drive and operate machinery
The use of the drug does not influence the ability to perform potentially hazardous activities requiring high concentration and quick psychomotor reactions (driving vehicles, operating moving mechanisms, operator’s work).
Contraindications
Individual intolerance, hypersensitivity to the ingredients, pregnancy, breast-feeding, children under 12 years of age, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
With caution
Patients with diabetes, children from 12 years.
Side effects
Allergic reactions, in some cases, laxative effect are possible. If side effects occur which are not described in these instructions, stop taking the drug and inform the attending physician.
Overdose
To date, no cases of overdose have been reported. In case of taking a dose exceeding several times the therapeutic, it is necessary to induce vomiting and gastric lavage, then take activated charcoal, if necessary undergo symptomatic treatment.
Pregnancy use
The drug is contraindicated in pregnancy and during breast-feeding (due to lack of data on efficacy and safety of use in this category of patients).
Similarities
Carsil, Legalon 140, Legalon 70, Silimar, Legalon
Weight | 0.015 kg |
---|---|
Shelf life | 5 years. |
Conditions of storage | At a temperature not exceeding 25 ° C, in the original package. Keep out of reach of children. |
Manufacturer | PharmVilar NGO, Russia |
Medication form | pills |
Brand | PharmVilar NGO |
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Buy Forliver Help, tablets 100 mg 30 pcs with delivery to USA, UK, Europe and over 120 other countries.