Folacin, tablets 5 mg 30 pcs

Folacin is a B vitamin. In the body it is converted to tetrahydrofolic acid as a coenzyme involved in various metabolic processes and necessary for normal maturation of megaloblasts and formation of normoblasts. When folic acid deficiency develops megaloblastic type of hematopoiesis. It stimulates erythropoiesis, participates in the synthesis of amino acids (including methionine, serine, glycine), nucleic acids, purines, pyrimidines, and in the metabolism of choline and histidine. During pregnancy, performs a protective function against the action of teratogenic and fetal damaging factors. Contributes to normal maturation and functioning of the placenta.

Pharmacokinetics

After oral administration, folic acid is absorbed in the gastrointestinal tract and is almost completely bound to plasma proteins. It is deposited and metabolized in the liver with the formation of tetrahydrofolic acid (in the presence of ascorbic acid under the action of the enzyme dihydrofolate reductase).

It penetrates through the HEB, the placenta and into the breast milk. T_max in blood is 30-60 minutes. It is excreted by the kidneys both unchanged (if the dose taken significantly exceeds the daily requirement) and as metabolites. Excreted by hemodialysis. 5 mg of folic acid taken orally is eliminated from the body in 5 hours.

Indications

Composition

1 tablet contains:

the active ingredient:

folic acid 5 mg,

excipients:

Lactose monohydrate – 133.92 mg;

MCC – 50 mg;

magnesium stearate – 1 mg;

povidone – 5.04 mg;

crospovidone – 5.04 mg.

How to take, the dosage

Folacin is administered orally.

For treatment of megaloblastic anemia caused by folic acid deficiency: 5 mg daily for 4 months, for prophylaxis – 2.5 mg daily.

For the prevention and treatment of macrocytic anemia in malabsorption, inflammatory bowel disease and unbalanced or incomplete nutrition: 15 mg daily, for patients with sprue disease: 5-15 mg daily.

To prevent fetal neural tube defects – 2.5 mg per day for 4 weeks before the intended pregnancy. The use is continued during the first trimester of pregnancy.

Higher maintenance doses of Folacin may be prescribed for patients with alcoholism, as well as patients with chronic infections and those taking anticonvulsants.

Interaction

In concomitant use with chloramphenicol, neomycin, polymyxins, tetracyclines absorption of folic acid is reduced.

In concomitant use folic acid reduces the effects of oral contraceptives, ethanol, sulfasalazine, cycloserine and glutethimide, methotrexate, phenytoin, primidone, chloramphenicol.

The use of folic acid may decrease plasma levels of phenobarbital, phenytoin, or primidone and cause an epileptic seizure.

Decreased or altered absorption is possible when colestyramine and folic acid are used simultaneously, so folic acid should be taken 1 hour before or 4-6 hours after colestyramine.

Special Instructions

Patients on hemodialysis need increased amounts of folic acid.

Long-term use of folic acid, especially in high doses, may decrease the blood concentration of vitamin B12.

Long-term use of the drug is recommended to be combined with intake of vitamin B12 (cyanocobalamin).

Contraindications