Fluimucil, 600 mg 10 pcs

Fluimucil liquefies sputum. The presence of sulfhydryl groups in the structure of acetylcysteine helps to break disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and to reduction of mucus viscosity. The drug retains activity in the presence of purulent sputum.

Acetylcysteine has an antioxidant effect due to the presence of the nucleophilic thiol SH-group, which easily gives off hydrogen, neutralizing oxidizing radicals.

Pharmacodynamics

The prophylactic use of acetylcysteine reduces the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis. The protective mechanism of acetylcysteine is based on the ability of its reactive sulfhydryl groups to bind chemical radicals.

Acetylcysteine readily penetrates the cell, is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector, trapping endogenous and exogenous free radicals and toxins.

Acetylcysteine prevents depletion and promotes the synthesis of intracellular glutathione, participating in the redox processes of cells, thus contributing to the detoxification of harmful substances. This explains the action of acetylcysteine as an antidote in paracetamol poisoning.

Pharmacokinetics

Fluimucil is well absorbed when taken orally. It is immediately deacetylated to cysteine in the liver. In the blood there is a dynamic equilibrium of free and bound to plasma proteins acetylcysteine and its metabolites (cysteine, cystine, diacetylcysteine). Because of the high “first pass” effect through the liver, the bioavailability of acetylcysteine is about 10%. Acetylcysteine penetrates into the intercellular space, predominantly distributed in the liver, kidneys, lungs, bronchial secretion.

After oral administration of 600 mg of acetylcysteine in healthy volunteers, Cmax in plasma is reached after approximately 1 hour and is 15 mmol/L. T1/2 from plasma is 2 hours. Acetylcysteine and its metabolites are excreted mainly by the kidneys.

Indications

Respiratory diseases, accompanied by the formation of highly viscous sputum (acute and chronic bronchitis, pneumonia, bronchiectasia, cystic fibrosis, asthma).

Active ingredient

Composition

1 lemon flavored fizzy drink tablet contains:

The active ingredient:

acetylcysteine 600 mg;

Associates:

citric acid;

sodium bicarbonate;

aspartame;

lemon flavoring

How to take, the dosage

1 tablet is dissolved in 1/3 cup of water and taken once a day.

The duration of treatment should be assessed individually.

In acute diseases the duration of treatment is from 5 to 10 days and up to several months in the treatment of chronic diseases (according to the doctor’s recommendation).

Interaction

Combined use of acetylcysteine with cough suppressants may increase sputum stasis due to suppression of the cough reflex.

In concomitant use with antibiotics such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, they may interact with the thiol group of acetylcysteine, which leads to decreased activity of both drugs.

Hence, the interval between the intake of these drugs should be at least 2 hours.

The simultaneous administration of acetylcysteine and nitroglycerin may increase the vasodilator and disaggregant effect of the latter.

Acetylcysteine eliminates the toxic effects of paracetamol.

Special Instructions

Caution is used in patients prone to pulmonary bleeding, hemoptysis, with liver disease, kidney disease, impaired adrenal function, patients with bronchial asthma and obstructive bronchitis (and under systematic monitoring of bronchial patency).

When dissolving acetylcysteine it is necessary to use glassware, avoid contact with metal and rubber surfaces. When opening the bag there may be a smell of sulfur, it is the smell of the active ingredient, not an indication of the poor quality of the drug.

Ampoule of Fluimucil is opened before use. The opened ampoule may be stored in the refrigerator for 24 hours. Using the drug from a previously opened ampoule for injection is prohibited.

The drug contains aspartame, so it is not recommended for patients with phenylketonuria (granules, effervescent tablets).

Contraindications

With caution, the drug should be prescribed to patients with liver and kidney diseases.

Side effects

The digestive system: rarely – heartburn, nausea, vomiting, diarrhea, stomatitis.

Allergic reactions: rare – skin rash, itching, urticaria, bronchospasm.

Others: rare – nasal bleeding, tinnitus, collapse, decreased platelet aggregation.

Local reactions: when parenteral administration mild burning sensation at the injection site is possible; when inhaled – reflex cough, local airway irritation, stomatitis, rhinitis; bronchospasm is rare (in this case we should prescribe bronchodilators).

Overdose

Acetylcysteine at doses of 500 mg/kg per day did not cause signs and symptoms of overdose.

Pregnancy use

Pregnant and breastfeeding use is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or baby.

Similarities