Flexen, rectal 100 mg, 12 pcs.

Flexen is an NSAID, a derivative of propionic acid. It has analgesic, anti-inflammatory and antipyretic effects.

The mechanism of action is related to inhibition of COX activity – the main enzyme of arachidonic acid metabolism which is a precursor of prostaglandins, that play the main role in pathogenesis of inflammation, pain and fever.

The pronounced analgesic effect of ketoprofen is caused by two mechanisms: peripheral (indirectly, through inhibition of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in central and peripheral nervous system and also due to the effect on biological activity of other neurotropic substances which play key role in release of pain mediators in the spinal cord).

Ketoprofen also has anti-bradykinin activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.

Indications

Flexen is for symptomatic treatment of the following inflammatory processes:

Active ingredient

Composition

1 suppository contains:

Active substance:

ketoprofen 100 mg;

Associates:

Semisynthetic solid glycerides,

Silica colloidal anhydrous.

How to take, the dosage

Retcally, 1 suppository 1-2 times a day. The maximum daily dose of the drug should not exceed 300 mg.

Interaction

Because ketoprofen binds significantly to proteins, doses of anticoagulants, diphenylhydantoin or sulfur-containing drugs should be reduced.

Special Instructions

With caution use Flexen simultaneously with acetylsalicylic acid and other NSAIDs, lithium preparations, antihypertensive agents, diuretics, methotrexate and antidiabetic agents.

Alcohol should be avoided during the use of the drug Flexen for systemic use.

Contraindications

The drug should not be used in the following cases:

Side effects

Gastrointestinal system: gastric pain, nausea, vomiting, diarrhea, flatulence; rarely – bleeding in the gastrointestinal tract; with rectal administration – tenesmus, liquid stools.

CNS disorders: rarely – asthenia, headache, dizziness.

Local reactions: with rectal use – burning.

Others: rare – transient dysuria, skin rash; with external use – skin allergic reactions (itching, urticaria).

Overdose

Treatment: no specific antidote; symptomatic therapy if necessary.

Pregnancy use

The use of the drug is contraindicated in pregnancy and during breastfeeding.

Similarities