Flexen is an NSAID, a derivative of propionic acid. It has analgesic, anti-inflammatory and antipyretic effects.
The mechanism of action is related to inhibition of COX activity – the main enzyme of arachidonic acid metabolism which is a precursor of prostaglandins, that play the main role in pathogenesis of inflammation, pain and fever.
The pronounced analgesic effect of ketoprofen is caused by two mechanisms: peripheral (indirectly, through inhibition of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in central and peripheral nervous system and also due to the effect on biological activity of other neurotropic substances which play key role in release of pain mediators in the spinal cord).
Ketoprofen also has anti-bradykinin activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.
Rheumatoid arthritis, Myositis, Myalgia (muscle pain), Headache, Neck pain, Joint pain (arthralgia), Inflamed tendons, Gout, Arthrosis, Arthritis, Lumbago, Osteoarthritis, Radiculitis, Sprains and strains, Sciatica, Toothache, Back Pain, Neuritis, Pain, Swelling after injuries and operations, Cancer, Adnexitis, Painful menstruation (algodysmenorrhea), Bursitis, Pain after injuries and operations, Otitis
Flexen is for symptomatic treatment of the following inflammatory processes:
- lumbosacral plexus problems;
- joint pain;
- rheumatoid arthritis;
- acute pain syndrome;
- ligament damage;
- renal colic;
- bone pain;
- postoperative pain;
1 suppository contains:
ketoprofen 100 mg;
Semisynthetic solid glycerides,
Silica colloidal anhydrous.
How to take, the dosage
Retcally, 1 suppository 1-2 times a day. The maximum daily dose of the drug should not exceed 300 mg.
Because ketoprofen binds significantly to proteins, doses of anticoagulants, diphenylhydantoin or sulfur-containing drugs should be reduced.
With caution use Flexen simultaneously with acetylsalicylic acid and other NSAIDs, lithium preparations, antihypertensive agents, diuretics, methotrexate and antidiabetic agents.
Alcohol should be avoided during the use of the drug Flexen for systemic use.
The drug should not be used in the following cases:
- acute gastrointestinal disorders;
- bleeding in the gastrointestinal tract;
- acute liver disorders;
- acute renal disorders;
- disorders in the hematopoiesis system, including leukopenia, hemophilia, thrombocytopenia;
- severe heart failure;
- localization of pain before or after cardiovascular surgery;
- pregnancy and lactation;
- high sensitivity to NSAIDs.
Phlexen should be used with extreme caution in patients with gastrointestinal disorders, renal, hepatic, bronchial asthma, urticaria, rhinitis, blood diseases, liver cirrhosis, diabetes, sepsis, cerebrovascular disease.
Gastrointestinal system: gastric pain, nausea, vomiting, diarrhea, flatulence; rarely – bleeding in the gastrointestinal tract; with rectal administration – tenesmus, liquid stools.
CNS disorders: rarely – asthenia, headache, dizziness.
Local reactions: with rectal use – burning.
Others: rare – transient dysuria, skin rash; with external use – skin allergic reactions (itching, urticaria).
Treatment: no specific antidote; symptomatic therapy if necessary.
The use of the drug is contraindicated in pregnancy and during breastfeeding.
Ketonal, OKI, Bystromgel, Febrofid, Flamax forte, Ketoprofen, Flamax, Fastum, Rocketal Rompharm, Pentalgin extra-gel, Ketonal DUO, Ketoprovel, OKI ACT, Brustel
|Conditions of storage|
At a temperature not exceeding 25 °C
Italpharmaco S.p.A., Italy
Buy Flexen, rectal 100 mg, 12 pcs. with delivery to USA, UK, Europe and over 120 other countries.