Favirox, 500 mg 21 pcs

How to take, the dosage

The drug should be taken orally, regardless of meals, without chewing, with water. Treatment with the drug should be started as soon as possible, immediately after the appearance of the first symptoms of the disease (tingling, itching and burning).

Infections caused by VZV (herpes zoster), including ophthalmoherpes in immunocompetent patients:

The recommended dose is 500 mg 3 times daily for 7 days.

Infection caused by VZV (herpes zoster) in immunocompromised patients:

The recommended dose is 500 mg 3 times daily for 10 days.

Infection caused by HSV (labial or genital herpes) in immunocompromised patients:

– For a first episode of genital herpes, the recommended dose is 250 mg 3 times daily for 5 days;

– For relapses of genital herpes, 1000 mg 2 times daily for 1 day or 125 mg 2 times daily for 5 days or 500 mg once, followed by 3 doses of 250 mg every 12 hours.

– For relapses of labial herpes – 1500 mg once daily for 1 day or 750 mg twice daily for 1 day.

Infection caused by HSV (orolabial or genital herpes) in immunocompromised patients:

The recommended dose is 500 mg twice daily for 7 days.

To prevent exacerbations of genital herpes (suppressive therapy), 250 mg 2 times daily is used. The duration of therapy depends on the severity of the disease. Periodic evaluation of possible changes in the course of the disease after 12 months is recommended.

In HIV-infected patients, the effective dose is 500 mg 2 times a day.

Patients aged ≥65 years

In elderly patients with normal renal function, dosing adjustment of famcyclovir is not necessary.

Patients with impaired renal function

Patients with impaired renal function have decreased clearance of penciclovir.

Recommendations for dosing regimen adjustment in immunocompetent patients with impaired renal function based on creatinine clearance are presented in Table 1.

Recommendations for dosing regimen adjustment in immunocompromised patients with impaired renal function as a function of creatinine clearance are presented in Table 2.

Table 1. Dosing regimen correction in immunocompromised patients with impaired renal function

< 20

Table 2. Dosing regimen correction in immunocompromised patients with impaired renal function

Patients with renal impairment who are on hemodialysis or receiving a hemodialysis procedure

Because penciclovir plasma concentrations are reduced by 75% after a 4-hour hemodialysis procedure, famiclovir should be taken immediately after the hemodialysis procedure. See Tables 1 and 2 for a recommended dose adjustment regimen.

Patients with hepatic impairment

There is no need for dose adjustment in patients with mild to moderate hepatic impairment.

There is no experience of using the drug in patients with severe hepatic impairment.

Patients of the Negro race

The efficacy of a 1-day dosage of famcyclovir 1000 mg twice daily for the treatment of genital herpes relapse in immunocompetent patients of the Negro race was not greater than that of placebo. The clinical significance of drug dosing regimens for the treatment of both genital herpes relapses (within 2 or 5 days) and other infectious lesions caused by VZV and HSV is unknown.

Interaction

Concomitant use with probenecid may increase the concentration of penciclovir in the blood plasma. To prevent the development of toxic reactions, patients receiving Favirox at a dose of 500 mg concomitantly with probenecid should be monitored, taking into account the possibility of reducing the dose of Famiclovir.

Special Instructions

Treatment should begin as soon as the diagnosis is made.

Synopsis

Filmed film-coated tablets, 500 mg:

Oval, biconvex, white film-coated tablets with marks on both sides of the tablet.

Contraindications

.

Side effects

Clinical studies have shown good tolerability of famcyclovir, including in patients with reduced immunity.