Enterosgel, paste 225 g

Pharmacological group

Entherosorbent.

Pharmacological action

Entherosgel has a porous structure of silicone matrix (molecular sponge) of hydrophobic nature, which is characterized by sorption action against only medium molecular weight toxic metabolites (m.m. from 70 to 1000).

Pharmacodynamics

Entherosgel has pronounced sorption and detoxification properties.

In the lumen of the gastrointestinal tract the preparation binds and removes from the body endogenous and exogenous toxic substances of various origins, including bacteria and bacterial toxins, antigens, food allergens, drugs and poisons, heavy metals and alcohol.

The preparation also sorbs some products of the body’s metabolism, including excessive bilirubin, urea, cholesterol and lipid complexes, as well as metabolites responsible for the development of endogenous toxicosis. Enterosgel does not reduce absorption of vitamins and microelements; it helps restore disturbed intestinal microflora and does not affect intestinal motility.

Pharmacokinetics

The drug is not absorbed in the gastrointestinal tract and is eliminated unchanged within 12 hours.

Indications

Enterosgel is used in adults and children as a detoxifying agent:

Active ingredient

Composition

100 g of paste for oral administration contains:

Active substances:

Polymethylsiloxane polyhydrate (non-linear polycondensation product of 1,1,3,3-tetrahydroxy-1,3-dimethyldisiloxane polyhydrate) 70 g.

Auxiliary substances:

Purified water – 30 g.

How to take, the dosage

Dosage and administration

Ingestion, 1-2 hours before meals or other drugs, with water.

It is recommended to take with water or dilute the dose in half a glass of water before taking.

Dosing regimen for different age groups

Dosing regimen depending on symptoms

For the prevention of chronic intoxication, one bag or 1.5 tablespoons (22.5 g) 2 times daily for 7-10 days, monthly.

Application in acute diarrhea:

After stopping diarrhea, take the drug for 5 days at the usual dosage.

In severe intoxication during the first three days, the dose of the drug may be doubled.

The duration of treatment in acute intoxications is 3-5 days, in chronic intoxications and allergic conditions – 2-3 weeks.

Repeated course – upon the doctor’s recommendation.

Interaction

It is possible to reduce absorption of other drugs when taking Enterosgel at the same time.

Special Instructions

Precautionary measures when taking the drug

Entherosgel can be used in combination therapy with other medicinal products with observance of the rule of separate time of taking – 1-2 hours before or after taking other drugs.

The results of recent published clinical trials (see Clinical guidelines “Obstetrics and gynecology”, 4th edition, revised and supplemented, M. GETAR-Media, 2014) allow us to recommend Enterosgel as part of the complex therapy of patients with endometritis and gestational pyelonephritis.

Entherosgel (polymethylsiloxane polyhydrate) has pronounced sorption and detoxification properties. In the gastrointestinal tract polymethylsiloxane polyhydrate binds and removes endogenous and exogenous toxic substances of various nature including bacteria and bacterial toxins, antigens, food allergens, metabolites of medicines and salts of heavy metals. The drug also sorbs metabolic products of the body, including excess bilirubin, urea, cholesterol and lipid complexes, as well as metabolites responsible for the development of endogenous toxicity. Polymethylsiloxane polyhydrate does not reduce absorption of vitamins and microelements, promotes restoration of disrupted intestinal microflora and does not affect its motor function.

Interaction with alcohol

There are no data on the interaction with alcohol.

Prescription conditions from pharmacies

The drug is approved for over-the-counter use.

Contraindications

The contraindication to the use of Enterosgel is:

Side effects

When the drug is used, the following may occur:

Overdose

Cases of overdose of Enterosgel have not been identified.

Pregnancy use

Enterosgel is not contraindicated in pregnancy and during lactation (breastfeeding).

In children it is possible to use from infancy.

Similarities