Enterofuryl, 200 mg capsules 16 pcs

Entrofuryl^® is a broad-spectrum antimicrobial drug with no systemic action used for treatment of diarrhea of infectious etiology. The drug Entherofuryl ^® contains the active substance nifuroxazide, a drug of the group of 5-nitrofuran derivatives.

The drug has a bactericidal and bacteriostatic effect against most pathogens of acute intestinal infections. Antimicrobial action of nifuroxazide is dose-dependent: thus, low and medium doses of the drug have a bacteriostatic effect against pathogenic microflora, and high – bactericidal.

Bacteriostatic mechanism of action of the drug is associated with inhibition of activity of the enzyme dehydrogenase, which leads to disruption of the normal course of synthesis of vital compounds in the cell of the microorganism.

Thus, due to the effect of nifuroxazide on a microorganism cell the respiratory chain is broken and the tricarboxylic acid cycle is suppressed. In addition, Enterofuryl^® inhibits protein synthesis in the microorganism cell and inhibits other biochemical processes in the bacterial cell. Thus, the microorganism cell loses its ability to reproduce.

Indications

Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.

Pharmacological effect

Antimicrobial agent, nitrofuran derivative.
Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell.
Destroys the microbial cell membrane, reduces the production of toxins by microorganisms.
Highly active against Campylobacterjejuni, Escherihia coli, Salmonella spp., Shigella spp., Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolylique, Staphylococcus spp.
Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes.
Resistant to nifuroxazide: klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.
Does not disturb the balance of intestinal microflora.

Special instructions

When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy.
In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs.
If symptoms of hypersensitivity appear (shortness of breath, rash, itching), you should stop taking the drug.
Drinking alcohol during nifuroxazide therapy is prohibited.
The drug does not affect the ability to drive vehicles and machinery.
During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug. You should consult your doctor.

Active ingredient

Nifuroxazide

Composition

1 capsule No. 0 contains:
Active ingredient: nifuroxazide 200.00 mg;
Excipients: sucrose 68.00 mg, corn starch 65.90 mg, cellulose powder 9.00 mg, magnesium stearate 7.10 mg;
Composition of the capsule shell (%): titanium dioxide (E 171) -2.95, iron dye yellow oxide (E 172) – 1.00, gelatin – q.s. up to 100.

Pregnancy

The use of the drug Enterofuril during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.

Enterofuril is not absorbed from the gastrointestinal tract and does not enter the systemic circulation, however, the use of the drug during lactation is possible only under strict indications, and the issue of stopping breastfeeding should be resolved.

Contraindications

Hypersensitivity to nifuroxazide, to nitrofuran derivatives and other components of the drug, pregnancy, children under 3 years of age (for this dosage form), fructose intolerance, glucose-galactose malabsorption syndrome, sucrase and isomaltase deficiency.
As a precaution, nifuroxazide is not recommended during pregnancy.

Side Effects

Allergic reactions (skin rash, urticaria, Quincke’s edema, anaphylactic shock).

Interaction

Concomitant use with drugs that cause disulfiram-like reactions is not recommended.

Overdose

Overdose symptoms are not known.

Short product description

Enterofuril® is a drug for initial treatment of intestinal infections. Eliminates the cause of diarrhea – harmful microbes and bacteria. Acts only in the intestinal lumen. Preserves normal intestinal microflora. Prevents the development of bacterial complications in viral diarrhea. More details at enterofuryl.ru

Storage conditions

At a temperature not exceeding 30 °C

Shelf life

5 years

Manufacturer

Bosnalek JSC, Bosnia and Herzegovina