Enterofuryl, 200 mg/5 ml suspension 90 ml
€14.43 €12.50
Entrofulil® is a broad-spectrum antimicrobial drug with no systemic action, used for treatment of diarrhea of infectious etiology.
The drug Entherofuryl® contains the active substance nifuroxazide, a drug of the group of 5-nitrofuran derivatives. The drug has a bactericidal and bacteriostatic effect against most pathogens of acute intestinal infections.
Antimicrobial action of nifuroxazide is dose-dependent: thus, low and medium doses of the drug have a bacteriostatic effect against pathogenic microflora, and high – bactericidal.
Bacteriostatic mechanism of action of the drug is associated with inhibition of dehydrogenase enzyme activity, which leads to disruption of the normal course of synthesis of vital compounds in the cell of the microorganism. Thus, due to the effect of nifuroxazide on the microbial cell there is a disruption of the respiratory chain and inhibition of the tricarboxylic acid cycle.
In addition, the drug Entherofuryl® inhibits protein synthesis in the microorganism cell and inhibits other biochemical processes in the bacterial cell. Thus, the microorganism cell loses its ability to reproduce.
Indications
Acute bacterial diarrhea, occurring without deterioration in general condition, increase in body temperature, or intoxication.
Pharmacological effect
Pharmacological action
Antimicrobial agent, nitrofuran derivative.
Blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell.
Destroys the microbial cell membrane, reduces the production of toxins by microorganisms.
Highly active against Campylobacterjejuni, Escherihia coli, Salmonella spp., Shigella spp., Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolylique, Staphylococcus spp.
Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes.
Resistant to nifuroxazide: klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.
Does not disturb the balance of intestinal microflora.
Special instructions
When treating diarrhea, rehydration therapy must be carried out simultaneously with nifuroxazide therapy.
Treatment of diarrhea in children under 3 years of age should be carried out under medical supervision.
In case of bacterial diarrhea with signs of systemic damage (deterioration of general condition, increased body temperature, symptoms of intoxication or infection), you should consult a doctor to decide on the use of systemic antibacterial drugs.
If symptoms of hypersensitivity appear (shortness of breath, rash, itching), you should stop taking the drug. Drinking alcohol during nifuroxazide therapy is prohibited.
During the lactation period, it is possible to continue breastfeeding in case of a short course of treatment with the drug. You should consult your doctor.
Active ingredient
Nifuroxazide
Composition
5 ml of suspension contain:
Active ingredient: nifuroxazide 200.0 mg;
Excipients: sucrose 1000.0 mg, sodium hydroxide 2.0 mg, methyl parahydroxybenzoate 5.0 mg, ethanol 960/0 0.05 ml, carbomer 0.5 mg, citric acid 0.75 mg, banana flavor 10.00 mg, water up to 5.0 ml
Pregnancy
The use of the drug Enterofuril during pregnancy is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
Enterofuril is not absorbed from the gastrointestinal tract and does not enter the systemic circulation, however, the use of the drug during lactation is possible only under strict indications, and the issue of stopping breastfeeding should be resolved.
Contraindications
Hypersensitivity to nifuroxazide, to nitrofuran derivatives and other components of the drug, pregnancy, neonatal period up to the first month, prematurity, fructose intolerance, glucose-galactose malabsorption syndrome, sucrase and isomaltase deficiency.
Side Effects
Allergic reactions (skin rash, urticaria, Quincke’s edema, anaphylactic shock).
Interaction
Concomitant use with drugs that cause disulfiram-like reactions is not recommended.
Overdose
Overdose symptoms are not known.
Short product description
Enterofuril® is a drug for initial therapy of intestinal infections. Eliminates the cause of diarrhea – harmful microbes and bacteria. Acts only in the intestinal lumen. Preserves normal intestinal microflora. Prevents the development of bacterial complications in viral diarrhea.
Storage conditions
At a temperature of 15-30 C. Shelf life: 3 years; after opening – 14 days
Shelf life
3 years.
Manufacturer
Bosnalek JSC, Bosnia and Herzegovina
Shelf life | 3 years. |
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Conditions of storage | At a temperature not exceeding 30 °C (do not freeze). |
Manufacturer | Bosnalek AS, Bosnia and Herzegovina |
Medication form | oral suspension |
Brand | Bosnalek AS |
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