Enam, tablets 20 mg 20 pcs

Enam® belongs to the medicines affecting the renin-angiotensin-aldosterone system (RAAS),
ACE inhibitors. ENAM® is used for treatment of essential hypertension (primary arterial hypertension (PH) of any severity and renovascular hypertension both in monotherapy and in combination with other hypotensive agents, particularly with diuretics.

Indications

Essential hypertension of any severity.
Renovascular hypertension.
Heart failure of any severity.
In patients with clinical manifestations of HF, Enam® is also indicated for:
increasing patient survival;
slowing the progression of heart failure;
reducing the frequency of hospitalizations for HF.
Prevention of the development of clinically significant heart failure.
In patients without clinical symptoms of heart failure with left ventricular dysfunction, Enam® is indicated for:
slowing down the development of clinical manifestations of heart failure;
reducing the frequency of hospitalizations for HF.
Prevention of coronary ischemia in patients with left ventricular dysfunction.
Enam® is indicated for:
reducing the incidence of myocardial infarction;
reducing the frequency of hospitalizations for unstable angina.

Pharmacological effect

Enam® is a drug that affects the renin-angiotensin-aldosterone system (RAAS),
– ACE inhibitors. The drug Enam® is used for the treatment of essential hypertension (primary arterial hypertension (AH)) of any severity and renovascular hypertension, both in monotherapy and in combination with other antihypertensive drugs, in particular with diuretics.

Special instructions

Symptomatic hypotension

Active ingredient

Enalapril

Composition

Each 2.5 mg, 5 mg, 10 mg and 20 mg tablet contains:

Pregnancy

The use of Enam® during pregnancy is not recommended.

Contraindications

Hypersensitivity to any of the components of the drug.

Side Effects

In general, Enam® was well tolerated.
In clinical studies, the total incidence of adverse events when using enalapril did not exceed that when taking placebo.

Interaction

When Enam is prescribed simultaneously with NSAIDs, the hypotensive effect of enalapril may be reduced;

with potassium-sparing diuretics (spironolactone, triamterene, amiloride) – hyperkalemia may develop;

with lithium salts – slowing down the excretion of lithium (monitoring the concentration of lithium in the blood plasma is indicated).
Ethanol enhances the hypotensive effect of the drug.

When used simultaneously with antipyretic and analgesic drugs, the effectiveness of Enam may be reduced.

Enalapril weakens the effect of drugs containing theophylline. Cimetidine prolongs the effect of enalapril.

Concomitant use with diuretics, beta-blockers, methyldopa, nitrates, calcium channel blockers,

hydralazine, prazosin enhances the hypotensive effect of enalapril.

The use of Enam together with anesthetics that have an antihypertensive effect can cause arterial hypotension

Overdose

Symptoms: arterial hypotension.

Treatment: the patient should be laid down, legs raised.

In mild cases of overdose, the patient is prescribed a saline solution orally.

In more serious cases, measures aimed at stabilizing blood pressure are carried out in a hospital setting; saline solution or plasma substitutes are administered intravenously.

Possible use of hemodialysis

Storage conditions

At a temperature not exceeding 25 °C.
Keep out of the reach of children!

Shelf life

3 years.

Manufacturer

Dr. Reddy’s Laboratories Ltd, India