Doritricin, tablets 10 pcs

Doritricin is a complex medication with an effect due to its constituent components.

Benzocaine is a local anesthetic that reduces pain on swallowing, which often accompanies infections and inflammations of the mouth and throat.

Benzalkonium chloride is a quaternary ammonium compound, belongs to cationic surfactants, interacts with lipoproteins and interferes with cell membrane permeability. It has antiseptic properties, is active against Gram-positive bacteria and has fungicidal effect against Candida albicans and some lipophilic viruses.

Tyrotricin is a topical antibiotic, which is a mixture of antimicrobial linear and cyclic polypeptides isolated at the stage of fermentation of Brevibacillus brevis Dudos, consisting mainly of gramicidin and tyrocidin. Tyrotricin acts bactericidally by disrupting phosphorylation processes in the cellular respiration chain and destroying bacterial cell membranes. Because of the special mechanism of action of tyrotricin, which is absent in antibiotics of systemic action, cross-resistance to the drug does not occur.

Pharmacokinetics

Benzocaine is slightly soluble in water, which causes its slow absorption. Like all etheric derivatives of para-aminobenzoic acid it is cleaved with esterase in plasma and liver. As a result, para-aminobenzoic acid and ethyl alcohol are formed, which is metabolized to acetyl coenzyme A.

Para-aminobenzoic acid undergoes conjugation with glycine or is excreted unchanged by the kidneys.

Benzalkonium chloride is practically not absorbed, has no resorptive effect and is excreted by the kidneys. No accumulation of the substance in body tissues has been found.

Tyrotricin – due to low systemic absorption there are no data on pharmacokinetics. Does not affect the intestinal microflora.

Indications

Infectious and inflammatory diseases of the oral cavity and pharynx, accompanied by pain:

inflammation of the gums and oral mucosa (gingivitis, stomatitis);
pharyngitis, laryngitis, initial stage of tonsillitis.

Pharmacological effect

Dorithricin is a complex drug, the effect of which is determined by its constituent components.

Benzocaine is a local anesthetic that reduces pain when swallowing, which often accompanies infectious and inflammatory processes in the mouth and throat.

Benzalkonium chloride is a quaternary ammonium compound, belongs to cationic surfactants, interacts with lipoproteins and disrupts the permeability of cell membranes. It has antiseptic properties, is active against gram-positive bacteria, and has a fungicidal effect on Candida albicans and some lipophilic viruses.

Tyrothricin is a local antibiotic, which is a mixture of antimicrobial linear and cyclic polypeptides isolated at the fermentation stage of Brevibacillus brevis Dudos, consisting mainly of gramicidin and tyrocidin. Tyrothricin acts bactericidal, causing disruption of phosphorylation processes in the chain of cellular respiration and destroying the membranes of bacterial cells. Due to the special mechanism of action of tyrothricin, which is absent in systemic antibiotics, cross-resistance to the drug does not occur.

Pharmacokinetics

Benzocaine is slightly soluble in water, which causes its slow absorption. Like all ether derivatives of para-aminobenzoic acid, it is cleaved by esterase in the blood plasma and liver. As a result, para-aminobenzoic acid and ethyl alcohol are formed, which is metabolized to acetyl coenzyme A.

Para-aminobenzoic acid undergoes conjugation with glycine or is excreted unchanged by the kidneys.

Benzalkonium chloride is practically not absorbed, has no resorptive effect and is excreted by the kidneys. No accumulation of the substance was detected in body tissues.

Tyrothricin – due to low systemic absorption, pharmacokinetic data are not available. Does not affect intestinal microflora.

Special instructions

Information for patients with diabetes: in 1 tablet of the drug the carbohydrate content is approximately 0.07 bread units (XE).

Impact on the ability to drive vehicles and other mechanisms that require increased concentration

No effect.

Active ingredient

Benzocaine, Benzalkonium chloride, Tyrothricin

Composition

Active ingredients:

benzalkonium chloride 1 mg;

benzocaine 1.5 mg;

tyrothricin 0.5 mg;

Excipients:

sorbitol 871 mg,

talc 80 mg,

povidone (polyvidone K25) 10 mg,

carmellose sodium 10 mg,

sucrose stearate 20 mg,

peppermint leaf oil 5 mg,

sodium saccharinate 1 mg.

Pregnancy

The use of Dorithricin during pregnancy and lactation is possible if the expected benefit to the mother outweighs the potential risk to the fetus.

Contraindications

Hypersensitivity;
hereditary fructose intolerance and glucose/galactose malabsorption syndrome or sucrase/isomaltase deficiency;
children under 6 years of age.

Side Effects

Allergic reactions are possible, rarely – gastrointestinal disorders (nausea, diarrhea).

If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.

Interaction

There are no cases of clinically significant interactions between Dorithricin and other drugs.

Overdose

No cases of overdose have been described at recommended doses.

Accidental intake of large doses of Dorithricin may cause disturbances in the digestive system (nausea, vomiting, diarrhea). In this case, you need to rinse your stomach, take activated charcoal and consult a doctor.

Storage conditions

Store at room temperature no higher than 25°C in a dry place, protected from light.

Shelf life

5 years.

Manufacturer

Medize Arzneimittel Pütter GmbH & Co. KG, Germany