Domstal, tablets 10 mg 30 pcs

Clinico-pharmacological groups: Antiemetic drug of central action, blocking dopamine receptors

Pharmacological action

An antiemetic drug. It has antiemetic effect, soothes hiccups and eliminates nausea in some cases. Its action is caused by the blockade of central dopamine receptors. Due to this, inhibitory influence of dopamine on motor function of gastrointestinal tract is eliminated and evacuatory and motility activity of the stomach is increased.

Indications

Nausea, vomiting, hiccups of different genesis (during toxemia, radiation therapy, dietary disorders, taking certain drugs /morphine/, endoscopic and X-ray contrast studies, in the postoperative period). Postoperative hypotension and atony of the stomach and intestines, biliary dyskinesia, flatulence, reflux esophagitis, cholecystitis, cholangitis, various types of dyspepsia. Nausea and vomiting caused by taking dopaminomimetics.

Active ingredient

Domperidone

Composition

Active ingredients: domperidone-10 mg

.

How to take, the dosage

Adults and children over 5 years of age – 10 mg 3 times a day 15-30 minutes before meals, and if necessary, an additional 10 mg before bedtime.

In severe cases of nausea and vomiting, severe dyspepsia – 20 mg 3-4 times a day.

In renal failure the frequency of use should be reduced.

Interaction

In concomitant use with antacids, antisecretory drugs (including cimetidine, sodium hydrocarbonate) the bioavailability of domperidone decreases.

In concomitant use with anticholinergic drugs the effect of domperidone is inhibited.

As domperidone is metabolized mainly with participation of CYP3A4 isoenzyme it is considered that simultaneous use of domperidone and inhibitors of this isoenzyme (including antifungal drugs of azole group, antibiotics of macrolide group, HIV protease inhibitors, nefasodone) may increase plasma level of domperidone.

Special Instructions

Use with caution in patients with liver and kidney dysfunction.

Contraindications

Gastrointestinal bleeding, mechanical intestinal obstruction, gastric or intestinal perforation, prolactinoma, children under 1 year of age (under 5 years and children with body weight under 20 kg – for tablets), hypersensitivity to domperidone, pregnancy, lactation (breastfeeding).

Side effects

CNS disorders: rarely – increased excitability and/or extrapyramidal disorders, headache.

Digestive system disorders: spasms of the smooth muscles of the gastrointestinal tract, dry mouth, thirst.

Allergic reactions: itching, rash, urticaria.

Others: increased plasma prolactin levels, galactorrhea, gynecomastia.

Pregnancy use

Domperidone is contraindicated in pregnancy and during lactation.

Similarities

Motilium, Passazhix, Motilac, Domperidon-Teva, Motonium, Domperidon, Motilium Express, Motogastric