Domstal, tablets 10 mg 30 pcs

Clinico-pharmacological groups: Antiemetic drug of central action, blocking dopamine receptors

Pharmacological action

An antiemetic drug. It has antiemetic effect, soothes hiccups and eliminates nausea in some cases. Its action is caused by the blockade of central dopamine receptors. Due to this, inhibitory influence of dopamine on motor function of gastrointestinal tract is eliminated and evacuatory and motility activity of the stomach is increased.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

In concomitant use with antacids, antisecretory drugs (including cimetidine, sodium hydrocarbonate) the bioavailability of domperidone decreases.

In concomitant use with anticholinergic drugs the effect of domperidone is inhibited.

As domperidone is metabolized mainly with participation of CYP3A4 isoenzyme it is considered that simultaneous use of domperidone and inhibitors of this isoenzyme (including antifungal drugs of azole group, antibiotics of macrolide group, HIV protease inhibitors, nefasodone) may increase plasma level of domperidone.

Special Instructions

Contraindications

Side effects

CNS disorders: rarely – increased excitability and/or extrapyramidal disorders, headache.

Digestive system disorders: spasms of the smooth muscles of the gastrointestinal tract, dry mouth, thirst.

Allergic reactions: itching, rash, urticaria.

Others: increased plasma prolactin levels, galactorrhea, gynecomastia.

Pregnancy use

Similarities