Dolobene, gel 90 g

Pharmacological group: Direct acting anticoagulant for topical use + other drugs.

ATX code: C05BA53

Pharmacological action:

Pharmacodynamics:

Dimethylsulfoxide (DMSO).

DMSO has anti-inflammatory, anti-edema and local analgesic effects.

The anti-inflammatory activity is associated with several pharmacological effects, the most significant of which is inactivation of hydroxyl radicals produced in large quantities during the inflammatory process and which have a damaging effect on tissue.

DMSO has a local analgesic effect by reducing the rate of conduction of nociceptive (pain) impulses in peripheral neurons. The antiedematous effect is provided by inactivation of hydroxyl radicals and improvement of the subcutaneous metabolic reaction at the site of application of the drug.

To a certain extent, the hygroscopic properties of DMSO are also responsible for its anti-edema effect. DMSO (50% and more) penetrates through biological membranes, including skin, facilitating better and deeper penetration into tissues of other drugs used simultaneously with it.

Heparin.

Heparin has anti-inflammatory effect, promotes regeneration of connective tissue by inhibiting the activity of hyaluronidase. Heparin shows dose-dependent antithrombotic effect, increasing the inhibitory activity of antithrombin III on prothrombin and thrombin activation. Heparin penetration through healthy skin is dose-dependent and is confirmed for doses starting at 300 IU/g.

Dexpanthenol.
When applied topically, dexpanthenol is transformed in the skin into pantothenic acid (B vitamin). The effectiveness of dexpanthenol is comparable with that of pantothenic acid. Pantothenic acid as a component of coenzyme A is involved in various catabolic and anabolic processes in tissues, by improving the processes of granulation and epithelialization promotes the regeneration of damaged skin.

Pharmacokinetics:

Dimethylsulfoxide (DMSO).

The physiologic plasma concentration of DMSO is normally 40 ng/ml. Six hours after application, the maximum plasma concentration reaches 120 ng/ml and lasts up to 12 hours after application.

Sixty hours after application, the plasma concentration of DMSO reaches a physiologic level of 40 ng/ml. 12-25% of absorbed DMSO is excreted within the first 24 hours and 37-48% is excreted within 7 days unchanged through the kidneys or as a metabolite (dimethylsulfone). 3.5-6% of total DMSO is excreted through the lungs as dimethylsulfide 6-12 hours after drug administration.

When 1 g of dimethylsulfoxide is used 3 times a day for 5 days, its average content in the application site on the skin is 3 mg/g, the average content in the underlying muscle tissues and synovial membrane in the synovial site is 7-10 µg/ml, in synovial fluid – 0.8 µg/g. The concentration of dimethylsulfoxide in blood plasma is 0.5 µg/g. Half-life of DMSO is 11-14 hours.

Heparin.

Heparin is insignificantly absorbed when used externally.

Dexpanthenol.

When applied externally, dexpanthenol is transformed in the skin into pantothenic acid. Good absorption of dexpanthenol has been confirmed experimentally.

Indications

Active ingredient

Composition

100 g of the gel contain:

Active ingredients:

Interaction

Directions for use

Special Instructions

Synopsis

Contraindications

Side effects

Overdose

Pregnancy use

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