Dolgit, gel 5% 100 g

NSAIDs

ATH code

M01AE01

Pharmacodynamics:The drug has a local analgesic and anti-inflammatory effect. Suppresses the production of inflammatory mediators. It selectively blocks cyclooxygenase (COX-1 and COX-2) and has an inhibitory effect on the synthesis of prostaglandin prostacyclin and thromboxane.

Analgesic effect is most pronounced for pain of inflammatory nature: the drug reduces pain at rest and during movement; reduces morning stiffness and joint swelling; helps to increase range of motion.

In addition to anti-inflammatory effect ibuprofen reduces platelet aggregation in the inflamed area, as well as migration of leukocytes and the release of lysosomal enzymes in the inflamed area.
Pharmacokinetics:

In application of gel on skin ibuprofen penetrates into deeper tissues (subcutaneous tissue, muscles, joint synovial fluid) and reaches therapeutic concentrations in them. The therapeutic effect in the area of application is achieved by direct distribution through the skin to the target tissues. In a small amount is determined in blood plasma. With the recommended method of application, the concentration in synovial fluid is about 2 µg/ml.

Indications

– Inflammatory and degenerative diseases of the musculoskeletal system: arthritis joint syndrome with gout exacerbation (rheumatoid psoriatic gout) periarthritis brachial-tibial spondylitis (Behterev’s disease) deforming osteoarthritis osteochondrosis with radicular syndrome radiculitis tendinitis tendovaginitis bursitis lumbago sciatica.

– Muscle pain (myalgia) of rheumatic and non-rheumatic origin.

– Trauma (sports, industrial and domestic, etc.) without violation of the integrity of the skin (sprains, sprains or tears of muscles and ligaments bruises post-traumatic soft tissue edema, etc.).

Active ingredient

Composition

100 g of the gel contains:

the active ingredient: ibuprofen 5 g;

How to take, the dosage

Interaction

Drug interactions with other drugs have not been described.

However, even when used topically, ibuprofen has a systemic effect, and theoretically there may be increased side effects if the gel is used simultaneously with other NSAIDs.

Special Instructions

In severe cases it is recommended to combine application of the gel externally with taking other dosage forms of NSAIDs (parenteral intra-rectally).

Contact of the gel to the eyes and mucous membranes should be avoided.

The use of the drug has no effect on activities requiring increased attention and coordination of movements and high speed of mental and physical reactions (e.g., drivers of vehicles and persons working with complex mechanisms, etc.).

Contraindications

Hypersensitivity to ibuprofen and other NSAIDs; bronchial asthma urticaria rhinitis provoked by taking acetylsalicylic acid; oozing dermatosis eczema skin integrity disorders at the application site of the gel, including infected wounds and abrasions; pregnancy (III trimester) children under 12 years of age.

Pregnancy (I-II trimester) lactation period.

Side effects

Overdose

No cases of overdose of the drug have been described.

In case of accidental ingestion of the drug, gastric lavage should be induced by gastric lavage and activated charcoal should be taken. Further treatment is symptomatic if necessary.

Similarities