Dolac, 30 mg/ml 1 ml 10 pcs

Pharmacological action – analgesic, antiaggregative, antipyretic, anti-inflammatory.

Inhibits cyclooxygenase (mainly in peripheral tissues), inhibits the synthesis of GH – modulators of pain sensitivity, thermoregulation and inflammation.

The analgesic effect develops after 1/2 hour, reaches its maximum after 1-2 hours and lasts 4-6 hours. It inhibits platelet aggregation, reduces the concentration of thromboxane and increases bleeding time.

Indications

Active ingredient

Composition

1 ml of solution for intravenous and intramuscular administration contains:

the active ingredient – ketorolaca tromethamine 30 mg;

excipients

How to take, the dosage

Internal, intravenous (by injection, for at least 15 seconds), intravenous (deep into the muscle, slowly). The dose is selected individually, taking into account the severity of the pain syndrome.

Single doses by injection in patients under 65 years of age – 10-30 mg every 4-6 hours. In patients older than 65 years or with impaired renal function – 10-15 mg, every 4-6 hours. By IV, in patients under 65 years of age 10-30 mg, every 6 hours (for continuous infusion, the initial dose is 30 mg, then at a rate of 5 mg/h); in patients over 65 years of age or with renal dysfunction, 10-15 mg every 6 hours by jetting. Duration of use is not more than 5 days.

Ingestion 10 mg up to 4 times daily. The highest daily dose is 40 mg. The course duration is not more than 7 days.

When switching from parenteral administration of the drug to oral administration, the total daily dose of both dosage forms on the day of transfer should not exceed 90 mg for patients under 65 years of age, and 60 mg for those over 65 years or with impaired renal function (at that, the dose of the drug in tablets should not exceed 30 mg).

Interaction

Acetylsalicylic acid and other NSAIDs mutually increase the risk of severe side effects.

Pentoxifylline and substances that affect hemostasis (warfarin, heparin, dextrans) increase the likelihood of bleeding.

Probenecid decreases plasma Cl and volume of distribution, increases plasma concentration, and T 1/2. Reduces the diuretic effect of furosemide. Concomitant use with ACE inhibitors may increase the risk of impaired renal function.

Special Instructions

Dolac solution for injection is incompatible in the same syringe with promethazine, hydroxyzine (precipitate); it is compatible with physiological solution, 5% glucose solution, Ringer’s solution, “Plasmalite” solution, as well as with infusion solutions containing aminophylline, lidocaine hydrochloride, dopamine hydrochloride, human insulin of short action and heparin sodium salt.

Contraindications

Hypersensitivity, including to other NSAIDs. NSAIDs, acute gastric and duodenal ulcer, history of ulcer, perforation or gastrointestinal bleeding, moderate to severe renal failure, risk of its development with hypovolemia or dehydration, hemorrhagic stroke, conditions with high risk of bleeding or incomplete hemostasis, preoperative period and during surgical intervention (because of high risk of bleeding); concomitant use of other NSAIDs, includingincluding aspirin and pentoxifylline; pregnancy, childbirth, breastfeeding, and under 16 years of age.

Side effects

Nervous system and sensory organs: headache, dizziness, nervousness, tremor, impaired ability to concentrate, asthenia, depression, hallucinations, paresthesias, seizures; taste and vision disorders.

Cardiovascular system and blood (hematopoiesis, hemostasis): decrease or increase in BP, palpitations, anemia, eosinophilia, thrombocytopenia, leukopenia.

Respiratory system: dyspnea, cough, bronchospasm, bronchial asthma, pulmonary edema.

Gastrointestinal system disorders: dry mouth, stomatitis, nausea, vomiting, feeling of full stomach, flatulence, constipation or diarrhea, dyspepsia, gastritis, peptic ulcers, rectal bleeding, melena.

Urogenital system disorders: hematuria, glomerulonephritis, nephrotoxic syndrome, acute renal failure, urinary retention, polyuria, frequent urination.

The skin: pale skin, itching, rash (including hemorrhagic), pain at the injection site.

Allergic reactions: anaphylaxis, anaphylactoid reaction, laryngeal edema, tongue edema.

Others: impairment of liver function.

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