Dipyridamol-FPO, 25 mg 100 pcs

Antiplatelet, angioprotector, immunomodulator. It has an inhibitory effect on platelet aggregation, improves microcirculation.

It has a vasodilator effect, reduces resistance of resistive coronary vessels (mainly arterioles), increases the volume velocity of coronary blood flow. It is able to decrease perfusion of ischemic zones of myocardium.

The mechanism of action is not fully clarified. It is believed that dipyridamole increases adenosine content (by disrupting its reuptake), and also promotes increase of the concentration of CAMF due to inhibition of FDE enzyme.

As a pyrimidine derivative, dipyridamole is an interferon inducer and has a modulating effect on the functional activity of the interferon system, increases reduced production of interferon alpha and interferon gamma by blood leukocytes in vitro. Increases nonspecific resistance to viral infections.

Indications

Treatment and prevention of cerebral circulation disorders of ischemic type, discirculatory encephalopathy.

Prevention of arterial and venous thrombosis and its complications, prevention of thromboembolism after cardiac valve replacement surgery.

Prevention of placental insufficiency in complicated pregnancy.

As a part of complex therapy for any microcirculatory disorders.

As an interferon inducer and immunomodulator for the prevention and treatment of influenza and acute respiratory infections.

Active ingredient

Composition

1 tablet contains:

The active ingredient:

dipyridamole – 25 mg;

Associated substances:

lactose monohydrate – 32.1 mg,

Microcrystalline cellulose – 30 mg,

croscarmellose sodium – 3 mg,

copovidone – 4 mg,

magnesium stearate – 0.9 mg.

Shell composition:

Hypromellose – 1.24 mg, polysorbate-80 – 0.24 mg, quinoline yellow dye – 0.02 mg, titanium dioxide – 0.5 mg.

How to take, the dosage

Unless otherwise prescribed by the physician, the following dosing regimens are recommended:

Dipyridimol at a dose of 75-225 mg/day in multiple doses is recommended to reduce platelet aggregation. In severe cases, the dose may be increased to 600 mg/day.

. For prophylaxis of thromboembolic syndrome, stent thrombosis and aortocoronal shunts, 50 mg along with ASA on the first day, then 100 mg, 4 times a day (withdraw 7 days after surgery if ASA is continued at a dose of 325 mg/day) or 100 mg 4 times a day for 2 days before surgery and 100 mg 1 hour after surgery (in combination with warfarin, if necessary).

For prevention of influenza and other acute respiratory diseases, especially during epidemics, take the following regimen: 50 mg/day once every 7 days for 4-5 weeks.

To prevent relapses, in patients with frequent respiratory viral infections, Dipyridamole is recommended to be taken according to the scheme: 100 mg/day (2 times 50 mg, 2 hours apart) once a week for 8 to 10 weeks.

Dipyridamole is recommended to be taken on an empty stomach, without chewing the coated tablets, with a small amount of liquid.

Interaction

Xanthine derivatives (coffee, tea) may weaken the vasodilatory and antithrombotic effect of Dipyridamole. The use of Dipyridamole simultaneously with direct and indirect anticoagulants (heparin) and thrombolytics or acetylsalicylic acid increases the risk of hemorrhagic complications, which should be considered when using together.

Dipyridamole may increase the effect of hypotensive drugs.

Dipyridamole may weaken the anticholinergic properties of cholinesterase inhibitors.

The antiaggregative effect is enhanced when taking cephalosporin antibiotics (cefamandole, cefaperazone, cefatetan), penicillin antibiotics, tetracyclines, chloramphenicol, beta-lactams, nicotinic acid.

The antacids decrease the maximum concentration due to reduced absorption.

Contraindications

– Acute myocardial infarction, unstable angina, widespread stenotic atherosclerosis of the coronary arteries.

– Subaortic aortic stenosis

– Decompensated heart failure

– Hypertrophic obstructive cardiomyopathy

– Arterial hypotension and hypertension

– Severe cardiac rhythm disorders

– Hemorrhagic diathesis

– Diseases with a tendency to bleeding (gastric and duodenal ulcers, etc.)

– Chronic obstructive pulmonary disease

– Hepatic and/or renal failure

– Hypersensitivity to the components of the drug.

With caution Period of lactation, childhood (under 12 years of age – lack of sufficient experience).

Side effects

Heart palpitations, bradycardia, thrombocytopenia, changes in the functional properties of platelets, bleeding, feeling of blocked ears, noise in the head, arthritis. Vomiting, diarrhea, epigastric pain, and symptoms such as weakness, dizziness, nausea, headache, myalgia, and rhinitis may occur. Usually these side effects disappear with long-term use of Dipyridamole.

As a result of its potential vasodilator effect, Dipyridamole at high doses may cause arterial hypotension, a feeling of “hot flashes” and tachycardia, and coronary bypass syndrome (at doses greater than 225 mg per day).

Hypersensitivity reactions of the type of rash or urticaria are possible.

If side effects occur, you should tell your doctor.

Overdose

Symptoms: transient hypotension.

Treatment: symptomatic (including administration of vasopressor agents).

Similarities