Dioxidin, 5 mg/ml 10 ml 10 pcs

A broad spectrum antibacterial bactericidal drug.

Active against Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp, Staphylococcus spp., Strentococcus spp., pathogenic anaerobes (Clostridium perfrigens), acts on bacterial strains resistant to other antimicrobial drugs, including antibiotics. It does not have a local irritant effect. The development of drug resistance of bacteria is possible. The mechanism of bactericidal action of hydroxymethylquinoxalindioxide is to damage DNA biosynthesis of the microbial cell, which causes morphological changes in the cell wall and the genetic material of the bacteria. When administered intravenously it is characterized by low therapeutic latitude, due to which it is necessary to strictly observe the recommended doses. Treatment of burn and purulent-necrotic wounds promotes faster clearing of the wound surface, stimulates reparative regeneration and marginal epithelization and favorably influences the course of the wound process.

In experimental studies the presence of teratogenic, embryotoxic and mutagenic action is demonstrated. After intravenous administration the maximal concentration in blood (Cmax) is 1 – 2 hours, therapeutic concentration of the drug in blood is maintained for 4 – 6 hours. The drug penetrates well and quickly into all organs and tissues and is well absorbed from the wound surface by local and external application. It is not metabolized in the body. It is excreted by kidneys. When repeated administration it does not accumulate in the body.

Indications

Treatment of various forms of purulent bacterial infection caused by sensitive microflora, when other chemotherapeutic agents are ineffective or poorly tolerated.

Pharmacological effect

Broad-spectrum antibacterial bactericidal drug.

Active against Proteus vulgaris, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp., Staphylococcus spp., Strentococcus spp., pathogenic anaerobes (Clostridium perfrigens), acts on strains of bacteria resistant to other antimicrobial drugs, including antibiotics. Does not have a local irritating effect. The development of drug resistance in bacteria is possible. The mechanism of the bactericidal action of hydroxymethylquinoxaline dioxide is to damage the biosynthesis of microbial cell DNA, which causes morphological changes in the cell wall and genetic material of bacteria. When administered intravenously, it is characterized by a small therapeutic width, and therefore strict adherence to the recommended doses is necessary. Treatment of burn and purulent-necrotic wounds promotes faster cleansing of the wound surface, stimulates reparative regeneration and marginal epithelization, and has a beneficial effect on the course of the wound process.

Experimental studies have demonstrated the presence of teratogenic, embryotoxic and mutagenic effects. After intravenous administration, the maximum concentration in the blood (Cmax) is 1-2 hours, the therapeutic concentration of the drug in the blood remains for 4-6 hours.

The drug penetrates well and quickly into all organs and tissues, is well absorbed from wound surfaces when used locally and externally. It is not metabolized in the body. Excreted by the kidneys. With repeated administrations it does not accumulate in the body.

Special instructions

The drug Dioxidin® is prescribed only for severe forms of infectious diseases or when other antibacterial drugs are ineffective, including cephalosporins of the II-IV generations, fluoroquinolones, carbapenems.

In case of chronic renal failure, the dose is reduced. If crystals fall out during storage (at temperatures below 15 ° C), they are dissolved by heating the ampoules in a boiling water bath while shaking until the crystals are completely dissolved (clear solution). If, when cooled to 36 – 38 ° C, the crystals do not fall out again, the drug is suitable for use.

The drug is used under strict medical supervision in a hospital setting. Jet IV administration is unacceptable!

Hydroxymethylquinoxaline dioxide has a narrow therapeutic window (strict monitoring of compliance with recommended doses is necessary), therefore it is necessary to strictly adhere to the recommended doses and not exceed them. To prevent adverse reactions, it is recommended to use it in combination with antihistamines and calcium supplements. If adverse reactions occur, the dose should be reduced, antihistamines should be prescribed, and if necessary, the drug should be discontinued.

When used in elderly people, age-related decline in renal function should be taken into account, which may require a reduction in the dose of the drug.

If age spots appear during intravenous administration, increase the duration of a single dose to 1.5-2 hours, reduce the dose, prescribe antihistamines or discontinue the drug.

Active ingredient

Hydroxymethylquinoxaline dioxide

Composition

Active ingredient:

hydroxymethylquinoxaline dioxide 5 mg.

Excipients:

water for d/i – up to 1 ml.

Pregnancy

During pregnancy and breastfeeding, the use of Dioxidin is contraindicated.

Contraindications

Individual intolerance to the drug, adrenal insufficiency (including a history), pregnancy, lactation, children (up to 18 years).

Side Effects

With intravenous administration, headaches, chills, increased body temperature, dyspeptic disorders (nausea, vomiting, diarrhea), muscle cramps, allergic reactions (rash, urticaria), photosensitizing effect (the appearance of pigmented spots on the body when exposed to sunlight) are possible. When used externally – itching, periwound dermatitis.

Interaction

In case of hypersensitivity to the drug, Dioxidin is used simultaneously with antihistamines or calcium supplements.

Overdose

In case of an overdose of hydroxymethylquinoxaline dioxide, acute adrenal insufficiency may develop, which requires immediate discontinuation of the drug and appropriate hormone replacement therapy.

Storage conditions

In a place protected from light at a temperature of 15 to 25 ° C.
Keep out of the reach of children.

Shelf life

2 years. Do not use after expiration date.

Manufacturer

Novosibkhimpharm, Russia