Diklo-F, eye drops 0.1% 5 ml

It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is due to non-selective inhibition of COX-1 and -2 activity, which leads to suppression of GH synthesis in the inflammation focus.

Diclofenac reduces ocular inflammation that may occur as a result of infection, trauma or surgery; it reduces miosis during surgery and reduces PG synthesis and their content in the moisture of the anterior chamber.

Pharmacokinetics

Diclofenac is absorbed into the systemic bloodstream during instillation of eye drops. However, the concentration of the drug substance reached in the blood is well below the detection limit and has no clinical significance.

Indications

Conjunctivitis, Eye burns, Corneal trauma, Inflammatory eye diseases

• inhibition of miosis during cataract surgery;

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• treatment of non-infectious conjunctivitis;
• treatment and prevention of inflammatory processes after surgical procedures on the eyeball;
• prevention of cystic macular edema after cataract operations;
• treatment and prevention of post-traumatic inflammatory process in penetrating and non-penetrating eyeball wounds (as a supplement to local antibacterial therapy).

Active ingredient

Diclofenac

Composition

Active substance:

diclofenac sodium – 1 ml

Auxiliary substances:

benzalkonium chloride – 0.1 mg;

dinatrium edetate – 1 mg;

boric acid, 15 mg;

tromethamine, 6 mg;

polyoxyl-35 castor oil – 20 mg;

povidone – 15 mg

sodium hydroxide or hydrochloric acid – to pH 7.7;

water for injection – to 1 ml.

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How to take, the dosage

Topically.

In order to inhibit intraoperative miosis, it is applied into the conjunctival sac for 2 hours at 30 minute intervals (4 times) before surgery.

To prevent cystic macular edema, 1 drop 3-4 times daily for 2 weeks after surgery.

Other indications: 1 drop 3-4 times a day, depending on the severity of the condition. The course of treatment may last from 1 to 2 weeks.

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Interaction

Concomitant use of this drug with diflunisal is not recommended (because development of gastrointestinal bleeding is possible) and other NSAIDs, including acetylsalicylic acid in high doses (3 g or more per day), sulfonylurea drugs, methotrexate.

The use together with lithium preparations, digitoxin, indirect anticoagulants leads to strengthening their effect.

If necessary, it is possible to use simultaneously with other eye drops, including those containing GCS. If necessary, a break of at least 5 minutes between applications is necessary to avoid washout of the active ingredients with the subsequent doses.

Special Instructions

Patients who use contact lenses should use Diclo-F only with the lenses removed and put them back on 15 minutes after injecting.

The bottle should be closed after each use. The pipette tip should not touch the eye.

Impact on driving and operating machinery

At the time of treatment, one must refrain from potentially hazardous activities requiring increased concentration and quick psychomotor reactions.

Contraindications

• blood disorder of unclear genesis;
• high sensitivity to acetylsalicylic acid or other NSAIDs;
• gastrointestinal erosive-ulcerative processes in the acute stage;
• high sensitivity to diclofenac or excipients of the preparation.

With caution when used with epithelial herpetic keratitis (including history), diseases causing bleeding disorders (including hemophilia, prolongation of bleeding time, tendency to bleed), and elderly patients.

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Side effects

In rare cases – burning eyes, blurred vision (immediately after injection); corneal clouding (cornea), iritis.

Allergic reactions: itching of the eyes, hyperemia, angioedema of the face, fever, chills, photosensitization, skin rash (mostly erythematous, urticaria), erythema multiforme, nausea, vomiting.

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Pregnancy use

There are no data on the use of the drug during pregnancy and lactation. When using NSAIDs in the third trimester of pregnancy, there may be an increased risk of fetal circulatory disorders. Use in pregnant and lactating women is possible only by prescription of a physician, if the expected therapeutic effect exceeds the risk of possible side effects.

There is no reliable data about using the drug in children; therefore the drug should only be used in this category of patients if the expected benefit exceeds the potential risk.

Similarities

Diclac, Diclofenac-Teva, Orthofen, Diclovit, Voltaren, Voltaren Emulsgel, Diclofenac, Voltaren Patch, Dicloran Plus, Orthofen, Diclofenac-Altfarm, Diclofenac-SOLofarm, Dialrapid