Diclofenac MFF, 2% ointment, 30 g

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic effects. Inhibits COX enzyme in the cascade of arachidonic acid metabolism and disrupts prostaglandin biosynthesis.
When used externally it has anti-inflammatory and analgesic effect. It reduces and relieves pain at the site of application of the ointment (including joint pain at rest and while moving), reduces morning stiffness and joint swelling. Helps to increase the volume of movement.

Indications

Active ingredient

Composition

Active ingredient: diclofenac sodium 20 mg;

Auxiliary substances: polyethylene oxide-400, polyethylene oxide-4000, 1,2-propylene glycol, nipagin, nipazol

How to take, the dosage

In a dose of 2-4 g, apply a thin layer to the skin over the inflammation and gently rub it in, the frequency of use – 2-3 times a day.
Maximal daily dose of the ointment shall not exceed 8 g.
The course of treatment is not more than 14 days. The need for longer use of the drug is determined by the doctor.

Interaction

Simultaneous use of the drug Diclofenac with digoxin, phenytoin or lithium drugs may increase plasma concentrations of these drugs; with diuretics and hypotensive agents – possible decrease in the effect of these drugs; with potassium-saving diuretics – possible development of hyperkalemia; with acetylsalicylic acid – decrease of plasma concentration of diclofenac and increased risk of side effects.
Diclofenac can increase toxic effect of cyclosporine on kidneys.
Diclofenac can cause hypo- or hyperglycemia, therefore simultaneous use with hypoglycemic agents requires blood glucose concentration control.
Administration of methotrexate during 24 hours before or after taking Diclofenac may increase methotrexate concentration and increase its toxic effect.
Concomitant use with anticoagulants requires regular monitoring of blood clotting.

Contraindications

Side effects

The application of the ointment may cause skin rash, burning, redness. With prolonged external use of the drug it is possible to develop systemic side effects on the digestive system, central nervous system, respiratory system, as well as allergic reactions.

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