Diclofenac, eye drops 0.1% 5 ml

NSAID, a derivative of phenylacetic acid. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect.

The mechanism of action is associated with inhibition of COX activity – the main enzyme of arachidonic acid metabolism, which is a precursor of prostaglandins that play a major role in the pathogenesis of inflammation, pain and fever.

Analgesic effect is caused by two mechanisms: peripheral (indirectly, through inhibition of prostaglandins synthesis) and central (due to inhibition of prostaglandins synthesis in central and peripheral nervous system).

Inhibits synthesis of proteoglycan in cartilage.

In rheumatic diseases it decreases joint pain at rest and while moving, as well as morning stiffness and joint swelling and helps increase movement volume. It reduces post-traumatic and post-operative pain, as well as inflammatory swelling.

Indications

For local use: inhibition of miosis during cataract surgery, prevention of cystoid macular edema associated with removal and implantation of the lens, inflammatory processes of the eye of a non-infectious nature, post-traumatic inflammatory process in penetrating and non-penetrating wounds of the eyeball.

Pharmacological effect

NSAID, phenylacetic acid derivative. It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect.

The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Inhibits proteoglycan synthesis in cartilage.

For rheumatic diseases, it reduces pain in the joints at rest and during movement, as well as morning stiffness and swelling of the joints, and helps to increase range of motion. Reduces post-traumatic and postoperative pain, as well as inflammatory swelling.

Special instructions

Use with extreme caution in patients with a history of liver, kidney, gastrointestinal diseases, dyspeptic symptoms, bronchial asthma, arterial hypertension, heart failure, immediately after major surgical interventions, as well as in elderly patients.

Active ingredient

Diclofenac

Composition

Composition of 1 ml of the drug:

Active substance:

diclofenac sodium – 1.0 mg.

Excipients: benzalkonium chloride, disodium edetate, boric acid, tromethamine, polyoxyl 35, castor oil, water for injection.

Contraindications

Erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, hematopoietic disorders of unknown etiology, hypersensitivity to diclofenac and components of the dosage form used, or other NSAIDs.

Manufacturer

Moscow Endocrine Plant, Russia