Dibicor, tablets 250 mg 60 pcs

Dibicor is metabolic.

Pharmacodynamics

Taurine is a natural product of the metabolism of sulfur-containing amino acids: cysteine, cysteamine, methionine. Taurine has osmoregulatory and membrane-protective properties, has a positive effect on the phospholipid composition of cell membranes, normalizes the exchange of calcium and potassium ions in cells.

Taurine has been shown to have inhibitory neurotransmitter properties, it has anti-stressor effect and may regulate the release of GABA, adrenaline, prolactin and other hormones, and regulate responses to them.

Participating in the synthesis of respiratory chain proteins in the mitochondria, taurine regulates oxidative processes and exhibits antioxidant properties and affects enzymes, such as cytochromes, responsible for the metabolism of various xenobiotics.

Dibicor^® improves metabolic processes in the heart, liver and other organs and tissues.

In chronic diffuse liver disease Dibicor^® increases blood flow and reduces the severity of cytolysis. Its treatment in case of cardiovascular insufficiency (CVI) decreases congestion in the small and large circulatory system: intracardiac diastolic pressure decreases, myocardial contractility increases (maximal contraction and relaxation rate, contractility and relaxation indices). The drug moderately decreases BP in patients with arterial hypertension and has practically no effect on BP in patients with CVD with lowered BP.

Dibicor^® reduces side effects from overdose of cardiac glycosides and slow calcium channel blockers; reduces hepatotoxicity of antifungal drugs. Improves performance under heavy physical exertion.

In diabetes mellitus, after about 2 weeks after the start of the drug Dibicor ^® blood sugar levels decrease. There is also a significant reduction of triglyceride concentration, to a lesser degree – of cholesterol level, reduction of plasma atherogenicity of lipids. Long-term use of the drug (about 6 months) showed improvement of the microcirculatory blood flow in the eye.

Pharmacokinetics

After a single administration of 500 mg of Dibicor^® the active ingredient (taurine) is detected in the blood in 15-20 min, C_max is reached in 1.5-2 h. The drug is completely eliminated after 24 hours.

Indications

Active ingredient

Composition

Tablets

Active substance:

Taurine250 mg;

Auxiliary substances:

MCC – 23 mg;

Potato starch – 18 mg;

Gelatin – 6 mg;

p> Colloidal silica (Aerosil) – 0.3 mg;

calcium stearate – 2.7 mg;

Pack of 60 pieces.

How to take, the dosage

Orally.

In case of heart failure, Dibicor® is taken orally at 250-500 mg (1-2 tablets of 250 mg or 1/2-1 tablets of 500 mg) 2 times a day 20 minutes before meals, treatment course is 30 days. The dose may be increased to 2-3 g/day (8-12 tablets of 250 mg or 4-6 tablets of 500 mg) or reduced to 125 mg (1/2 tablet of 250 mg) per dose.

In intoxication with cardiac glycosides, at least 750 mg/day (3 tablets of 250 mg or 1.5 tablets of 500 mg).

In case of type 1 diabetes mellitus, 500 mg (2 tablets of 250 mg or 1 tablet of 500 mg) 2 times daily in combination with insulin therapy for 3-6 months.

In type 2 diabetes mellitus, 500 mg (2 tablets of 250 mg or 1 tablet of 500 mg) 2 times daily as monotherapy or in combination with other oral hypoglycemic agents.

In case of type 2 diabetes, including with moderate hypercholesterolemia, 500 mg (2 tablets of 250 mg or 1 tablet of 500 mg) 2 times per day, the course length – as recommended by the physician.

As a hepatoprotective agent – 500 mg (2 tablets of 250 mg or 1 tablet of 500 mg) 2 times a day during the course of taking antifungal drugs.

Interaction

Dibicor® can be used with other drugs; it enhances the inotropic effect of cardiac glycosides.

Special Instructions

During administration of Dibicor the dose of cardiac glycosides should be reduced sometimes by half, depending on the sensitivity of patients to cardiac glycosides.

The same rule applies to “slow” calcium channel blockers.

Contraindications

Hypersensitivity to the drug; age under 18 years (efficacy and safety not established).

Side effects

Allergic reactions to the ingredients of the drug are possible.

Similarities