Detralex, 500 mg 60 pcs

Detralex® has venotonic and angioprotective properties.

The drug reduces venous distensibility and venous stasis, reduces capillary permeability and increases their resistance. The results of clinical studies confirm the pharmacological activity of the drug with respect to indicators of venous hemodynamics.

A statistically significant dose-dependent effect of the drug Detralex® has been demonstrated for the following venous plethysmographic parameters: venous capacity, venous distensibility, and time of venous emptying. The optimal dose/effect ratio is observed with the administration of 2 tablets.

Detralex® increases venous tone: venous occlusion plethysmography has been shown to decrease venous emptying time. In patients with signs of severe microcirculatory disturbances a statistically significant increase in capillary resistance as assessed by angiostereometry after therapy with Detralex® was observed (statistically significant) compared to placebo.

Therapeutic efficacy of Detralex® has been proven in the treatment of chronic diseases of lower limb veins and in the treatment of hemorrhoids.

Pharmacokinetics

The main excretion of the drug is in the feces. About 14% of the administered amount of the drug is excreted with urine on average.

The T1/2 is 11 hours.

The drug undergoes active metabolism, which is confirmed by the presence of phenolic acids in the urine.

Indications

Symptomatic therapy of venous and lymphatic insufficiency, feeling of heaviness in the legs, pain, “Morning fatigue” of the legs, cramps, trophic disorders, symptomatic therapy of exacerbation of hemorrhoids.

Active ingredient

Composition

1 tablet contains:

Active ingredients:

Purified micronized flavonoid fraction 500 mg ( including diosmin (90%) 450 mg,

flavonoids expressed as hesperidin (10%) 50 mg).

Auxiliary substances:

gelatin,

magnesium stearate,

microcrystalline cellulose,

How to take, the dosage

The drug is taken orally.

The recommended dose is 2 tablets a day, 1 tablet in the middle of the day and 1 tablet in the evening with a meal.

During exacerbation of hemorrhoids – 6 tablets per day for 4 days, then 4 tablets per day for the next 3 days.

Special Instructions

In acute hemorrhoids, prescribing this medication does not replace the specific treatment of other anal abnormalities. The duration of treatment should not exceed the recommended duration. If symptoms do not disappear after a short therapy, a proctologic examination should be performed and the therapy should be reviewed.

In the presence of venous circulatory disorders, the maximum effect of treatment is achieved in combination with a healthy, well-balanced lifestyle, in which it is advisable to avoid long exposures to the sun, reduce body weight, walk and in some cases wear special socks to improve blood circulation.

Impact on the ability to drive and operate machinery

The drug does not affect the ability to drive vehicles and perform work requiring high speed psychomotor reactions.

Contraindications

Hypersensitivity to the components of the drug.

Side effects

CNS disorders: rarely – dizziness, headache, general malaise.

Gastrointestinal disorders: often – diarrhea, dyspepsia, nausea, vomiting; rarely – colitis.

The skin: rare – rash, itching, urticaria; unspecified frequency – isolated swelling of the face, lips, eyelids. In exceptional cases – angioedema.

Pregnancy use

Pregnancy

There have been no animal experiments showing teratogenic effects.

Till now there have been no reports of any side effects when using the drug in pregnant women.

Breastfeeding

Because of lack of data regarding excretion of the drug into breast milk, it is not recommended for breastfeeding women to take the drug.

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